Angelina Jolie decided to have her breasts, ovaries and fallopian tubes removed after finding out she carried a mutation in the BRCA1 cancer suceptibility gene. A large study by researchers at Yale University looking at the genes of 50,000 people has revealed that 8 out of 10 people with a known cancer risk gene don't know they have it, despite them frequently engaging with the healthcare system. The study, published today in JAMA Network Open looked for changes in the BRCA1 and BRCA2 genes, which are known to increase the risk of breast, ovarian, prostate and pancreatic cancer in those who have them. Angelina Jolie famously decided to get a double mastectomy, followed by removal of her ovaries and fallopian tubes after discovering she had a mutation in the BRCA1 gene.
Genomic screening of more than 50,000 people shows that more than 80% of those who carry an identifiable genetic risk for breast, ovarian, prostate, and pancreatic cancer don't know it despite frequent interaction with the healthcare system. The findings were published Sept. 21 in the journal JAMA Network Open. In the absence of routine screening, most people only discover they carry cancer-associated variants in the BRCA1 or BRCA2 genes when that person or family members receive a cancer diagnosis. "As a colleague said, it usually takes a tragedy for people to get tested," said Michael Murray, professor of genetics at Yale School of Medicine and senior author of the study conducted at Geisinger
Celebrity astrologer Susan Miller has worked with some of the biggest names in Hollywood, including Khloe Kardashian, Cameron Diaz, Kirsten Dunst, Lindsay Lohan, Jennifer Aniston, Justin Theroux, Jessica Alba and Pharrell Williams -- but she has a particularly special bond with Pharrell. During a recent interview with TooFab, Susan revealed that the R&B crooner/producer reached out to her a few years ago about expanding his family. Not only did Susan let him know it was "definitely possible" for his wife, Helen Lasichanh, to conceive, but she also accurately predicted their babies' due date. "Pharrell had said, 'You know, we'd like to have more children. I love Rocket. I want more children,'"
From its nominees to its presenters, a look back at the Emmy Awards’ long track record of unforgettable hair and makeup moments.
Leave Not One Alive: Melissa Leo & Bella Thorne to star in thriller Deadline reports that Melissa Leo and Bella Thorne have been cast in the lead roles in Leave Not One Alive. Production is underway for the forthcoming indie revenge thriller which is now filming in New York. In addition to Leo and Thorne, Jake Weary (It Follows), Michael Potts (The Wire), Benedict Samuel (Gotham), Kevin Corrigan (The Departed), and Adrian Martinez (I Feel Pretty) are also set to star in the feature. The thriller follows the story of theater actress, Lillian Cooper (Leo) whose son (Weary) dies mysteriously. When the investigating officer (Potts) rules the cause of death an accidental overdose, Lillian conducts
"Shadow of the Tomb Raider" is one the prettiest games ever made, offering enhanced graphics on the Xbox One X, PlayStation 4 Pro, and PC. This is "Tomb Raider" at its peak — in the new game, Lara Croft explores the jungles of Peru in a massive open world that's filled with hidden crypts, wildlife and treasure. Developer Eidos Montreal hired cultural advisors to help ensure that its depiction of the indigenous people and locales in "Shadow of the Tomb Raider" was both accurate and respectful.
Produced with meager resources, “Path to Redemption” sneakily professes itself as a sort-of sequel to Angelina Jolie’s 2014 sophomore directorial effort “Unbroken,” even though they don’t share any cast members, below-the-line crew, or screenwriters. The bond between the two films is limited to having Laura Hillenbrand’s non-fiction literary work “Unbroken: A World War II Story of Survival, Resilience, and Redemption” as a mutual source material in telling two separate parts of POW and Olympian Louis Zamperini’s story.
Brad Pitt's legal woes go beyond just his poisonous divorce from Angelina Jolie: His New Orleans charitable foundation has been sued for allegedly building shoddy homes post-Hurricane Katrina and failing to fix multiple problems for nearly a decade. A group of more than 100 homeowners in the low-lying Lower Ninth Ward, one of the city's neighborhoods most damaged by the 2005 hurricane, filed a proposed class-action lawsuit last week accusing Pitt and his Make It Right foundation of unfair trade practices, breach of contract and fraud. Ron Austin, the New Orleans lawyer who represents the homeowners, says Pitt and the board of the foundation, which Pitt formed in 2007 after raising $42 million, have known about the problems since at least 2009 but have failed to fix them despite mounting complaints.