Z-Pak for Sinus Infection: Is It Necessary?
Medically reviewed by Femi Aremu, PharmD
Sinus infections are a common problem, affecting millions of people each year. Viruses, bacteria, or fungi can cause them. In most cases, sinus infections will go away within a few weeks, and antibiotics may not be necessary. However, your healthcare provider may prescribe antibiotics if your sinus infection is severe or does not improve with home treatments.
A Z-Pak is a five-day course of azithromycin that has been a common antibiotic for sinus infections. Azithromycin is in the class of antibiotics known as macrolides. It prevents bacteria from multiplying. However, it is not a recommended first-line therapy due to the high rate of antibiotic resistance for macrolides.
This article will discuss when it is necessary to treat your sinus infection with an antibiotic, whether Z-Pak is a good option, and other available antibiotics.
Getty Images / digicomphoto
What Is a Z-Pak?
A Z-Pak is a five-day course of azithromycin, which is an antibiotic. It treats various bacterial infections, including sinus infections, pneumonia, and ear infections. Azithromycin is also used to treat sexually transmitted infections (STIs) such as chlamydia and gonorrhea.
Can a Z-Pak Treat a Sinus Infection?
Yes, a Z-Pak can be an effective treatment for bacterial sinus infections. However, it is ineffective against viral sinus infections, which account for most sinus infections. Moreover, a Z-Pak is no longer the recommended go-to antibiotic due to the risk of resistance. Instead, it is more likely to be used as a substitute for penicillin antibiotics when a person has a penicillin allergy.
Viruses cause most sinus infections. Viral sinus infections usually go away within seven to 10 days. However, if your symptoms are severe or do not improve after 10 days, you may have a bacterial sinus infection.
It is crucial to see a healthcare provider to get a diagnosis. Your healthcare provider will be able to determine whether a bacterium or virus is causingyour infection.
How Long Will a Z-Pak Take to Work
Most people will start to feel better within a few days of taking a Z-Pak for a sinus infection. However, the infection may take up to a week to completely clear. If you do not start to feel better after a few days of taking a Z-Pak, or if your symptoms get worse, you should see your healthcare provider.
Side Effects of a Z-Pak
Azithromycin is generally well-tolerated, but it can cause some side effects. Some of the most common side effects of azithromycin are :
Diarrhea
Nausea
Vomiting
Stomach pain
Headache
Dizziness
Safety Warning About Z-Pak
The Food and Drug Administration (FDA) warns about the risk of abnormal changes in the electrical activity of the heart and irregular heart rhythm with the use of azithromycin. This is known as QT prolongation. You may be at increased risk if you:
Have existing QT interval prolongation
Have a slower-than-normal heart rate
Use certain medications designed to treat irregular heart rhythms
What Other Antibiotics Can Treat a Sinus Infection?
Other antibiotics can treat bacterial sinus infections, including:
Amoxicillin or amoxicillin-clavulanate: Amoxicillin is often prescribed as a first-line therapy for most adults.
Doxycycline: Doxycycline is often reserved for use in people who are allergic to penicillin-type antibiotics.
Levofloxacin or moxifloxacin. Fluoroquinolones levofloxacin or moxifloxacin may be used in some cases for people with a penicillin allergy.
Your healthcare provider can prescribe the best antibiotic for you based on your circumstances.
When to See a Healthcare Provider
If you think you may have a sinus infection, it is essential to see a healthcare provider to get a diagnosis. Your healthcare provider will be able to determine whether bacteria or a virus is the cause of your infection and will prescribe the appropriate treatment.
You should see a healthcare provider if:
Your sinus infection is severe, does not improve with home treatment, or gets worse after improving.
Your symptoms last more than 10 days.
You have a fever over 101 degrees F or a fever lasting longer than three to four days.
You have pain or pressure in your face or forehead.
You have difficulty breathing or sleeping.
Summary
Although antibiotics may be necessary for a bacterial sinus infection, most infections are viral and will resolve on their own with time. However, you should seek care if your symptoms are severe or last longer than 10 days.
While Z-Pak was once a popular antibiotic remedy, it is no longer recommended as a first-line therapy due to the high rate of bacteria resistant to macrolides in the United States. If you have a bacterial sinus infection, you will most likely be prescribed amoxicillin unless you have a penicillin allergy.
If you have sinus infection symptoms, seeing a healthcare provider for a diagnosis is vital. It is important to take all of your antibiotics even if you start to feel better to prevent recurrence or drug resistance.
Frequently Asked Questions
Is a Z-Pak better than amoxicillin for a sinus infection?
Sinus infections can be effectively treated with a Z-Pak or the amoxicillin antibiotic. What's the most suitable depends on your circumstances. Your healthcare provider is best positioned to recommend the most appropriate antibiotic by weighing your symptoms, medical history, and other relevant factors.
For instance, while amoxicillin is highly effective, individuals allergic to penicillin require a different antibiotic, such as azithromycin, which has also been proven to treat sinus infections effectively.
What else can I do to find symptom relief from a sinus infection?
There are many things you can do to find symptom relief from a sinus infection:
Drink plenty of fluids.
Use a humidifier or take a hot shower to help loosen mucus.
Get plenty of rest.
Avoid smoking and secondhand smoke.
Use over-the-counter pain relievers, such as ibuprofen or acetaminophen.
Use nasal saline sprays or rinses.
Use cough drops or lozenges.
Will a sinus infection clear up without antibiotics?
Most sinus infections will clear up on their own. However, some people may need antibiotics to treat a bacterial infection. If you have a severe sinus infection or your symptoms do not improve after a few days, you may need to see a healthcare provider for antibiotics.
It is important to note that taking antibiotics when they are not necessary can lead to antibiotic resistance. Antibiotic resistance is a serious problem that makes it more challenging to treat future infections.
If you have a sinus infection, seeing a healthcare provider to get a diagnosis is essential. Your healthcare provider will be able to determine whether you have a bacterial infection and, if so, whether antibiotics are necessary.
The author would like to recognize and thank Leen Alyaseen for contributing to this article.
Read the original article on Verywell Health.
