Watch Brian and Stewie from ‘Family Guy’ Explain the Vaccine

Family Guy creator Seth MacFarlane is doing his part to raise vaccine awareness by having his famous characters do the talking in a new PSA. The short film, released on Monday, begins with Peter Griffin visiting the doctor's office accompanied by Brian and Stewie, and expressing some uncertainty over whether or not to take the Covid vaccine.

Stewie then whips out his teleportation device and transports himself and Brian directly into Peter's bloodstream, where he launches into an explanation of exactly how vaccines work, both in general, and in relation to Covid, using some in-universe humor (for instance, the Covid spike protein resembles the frequently maligned Meg Griffin).

The PSA was created in partnership with The Ad Council's It's Up To You initiative, which aims to educate viewers about the virus.

"With millions of Americans still unsure about getting vaccinated against COVID-19, it's more important than ever that we have smart, informative and entertaining messages like this that will boost confidence in the vaccines," said Ad Council CEO Lisa Sherman. "This new work from Seth MacFarlane and the team at Family Guy is bringing critical vaccine information to audiences in a fresh and hilarious way that will surely inspire people to take the next step in slowing the pandemic. We are grateful to our partners at Disney and Fox for their passion and collaboration at this pivotal moment in time."

Richard Appel and Alec Sulkin, executive producers on the long-running animated sitcom, stated: "We were proud to work with some of the nation’s leading immunologists and epidemiologists on this PSA. And while we never understood a single note they gave us, we took them all."

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