CBD vs. THC for Anxiety
Medically reviewed by Lindsay Cook, PharmD
There are many Food and Drug Administration (FDA)–approved prescription drug treatments for anxiety. However, some people find the potential of a natural alternative an attractive option.
Some studies have shown that about 25% of people with mood or anxiety disorders have tried cannabis (also referred to as marijuana) to treat symptoms of anxiety.
Questions persist surrounding how the primary compounds in cannabis, CBD (cannabidiol) and THC (delta9-tetrahydrocannabinol), differ from one another, as well as what role each plays in creating therapeutic effects related to anxiety relief.
This article will discuss the use of CBD vs. THC for anxiety relief.
Getty Images / Vanessa Nunes
CBD vs. THC: What's the Difference?
Cannabis, with CBD and THC as its primary compounds, comes from the Cannabis sativa plant, which contains over 400 components.
CBD
CBD comes from both hemp and non-hemp plants and traditionally contain 0.0% to 0.3% THC.
CBD does not have a mind-altering effect.
It is a compound found in cannabis but does not cause the "high" that is commonly associated with using the drug.
CBD can be taken in various ways as an independent product, such as by mouth (liquids, capsules) or applied topically (lotions, creams).
THC
THC, a psychoactive compound, is believed to be responsible for producing the mind-altering effect of cannabis.
Notably, if someone consumes THC, they are consuming cannabis. There is no way to take THC as an individual compound.
What Is CBD (Cannabidiol)?
By itself, people use CBD to help with various conditions, such as:
Pain
Addiction, otherwise known as substance use disorder (SUD)
You can buy CBD products (containing 0.3% THC or less) within the United States at different locations, including pharmacies and dispensaries (stores that sell cannabis).
However, state laws can differ, so it's best to check your state laws for more information.
CBD In Prescription Drugs
CBD is also available in a prescription drug called Epidiolex (cannabidiol), which is an oral liquid medication that can be used to treat certain types of seizures.
However, Epidiolex is not FDA-approved for any other conditions, such as insomnia or anxiety.
Administering CBD
CBD is available in multiple forms to suit individual preferences and conditions. For example, if you have muscle pain, you may opt for a topical cream applied to one body part.
Examples of CBD products include:
Oils
Oral liquids
Spray that is administered under the tongue
Oral capsules
Patches that are applied to the skin
Vape
Topical products like creams and lotions
What Is THC (Delta-9-Tetrahydrocannabinol)?
Popular uses for cannabis, by which individuals consume the combination of effects of THC and CBD, include, but are not limited to:
Purchasing Cannabis
The best place to purchase cannabis is at a state-licensed dispensary. You may have heard the terms recreational (adult-use) cannabis and medical (or medicinal) cannabis.
While the products are the same and contain similar amounts of THC, the difference is in how they are sold, such as:
Anyone 21 years and older can purchase recreational cannabis in a state where it is legal.
To purchase medical cannabis through a state's medical program, an individual must have a qualifying condition that is approved by the state (approved conditions vary by state) and a healthcare provider's authorization.
Administering THC
Notable ways people consume cannabis include:
Smoking in hand-rolled cigarettes called joints
Smoking in pipes called bongs
Smoking in blunts (cigars that have been emptied and filled with cannabis)
Vaping
Through edibles (mixed into brownies, cookies, or candy)
Brewed as a tea
Dabbing (smoking or eating THC-rich resins extracted from the cannabis plant)
CBD vs. THC for Anxiety
Regarding their effects in alleviating symptoms of anxiety, studies show that CBD may reduce anxiety, while THC may help anxiety at low doses but not higher ones.
Clinical studies have found the following:
In one older (2011) small study, a group of people were given either CBD or a placebo before a public speaking event. The participants who took CBD had less anxiety than those who took the placebo.
A 2021 study found that CBD helped people with moderate to severe anxiety but did not help those with mild anxiety.
A review of studies by Drexel University's Medical Cannabis Research Center found that lower doses of THC help anxiety symptoms, but higher doses of THC may increase anxiety. The researchers also noted that CBD tends to decrease anxiety, regardless of the dose. The study also noted that CBD or THC should be used in addition to, not in place of, talk therapy (psychotherapy).
A 2022 study found that using cannabis to treat certain conditions (pain, anxiety, or depression) did not improve symptoms and also doubled the risk of developing cannabis use disorder (CUD). People with CUD build up a tolerance to THC and need to use more cannabis as a result. They may also continue to use cannabis despite its causing physical or psychological issues. People using cannabis for anxiety and depression had the highest risk of CUD.
Dosing Guidelines for Anxiety
Check with a healthcare provider before trying CBD or THC to make sure they are safe for you.
When using CBD for anxiety, you usually start with a low dose and gradually increase the dose to 300–400 milligrams (mg) per day.
Different formulations have different dosing, so ask your pharmacist or healthcare provider about dosing with your chosen product.
With THC, lower doses (7.5 mg or less) are more effective for anxiety, per past research.
However, the benefits may be temporary, and using cannabis regularly tends to increase the risk of tolerance to its effects, which could lead to cannabis dependence.
If you opt for THC, go to a state-licensed dispensary and consult the pharmacist (if there is one on staff) or a "budtender" (a dispensary staff member who can answer questions and offer suggestions) to learn more about the products and how to start with a very low dose.
When to Avoid CBD or THC
Before you use either CBD or THC, check with your healthcare provider to make sure it is safe for you to use.
Inform your provider of your medical history and current and prior conditions, as well as all of the medications you take, including:
Prescription drugs
Over-the-counter (OTC) medicines
Vitamins
Supplements
If you have ever had an allergic reaction to CBD, THC, or any cannabis product, you should avoid these products.
Use During Pregnancy or Breastfeeding
You should not take CBD or THC if you are pregnant or breastfeeding.
The FDA strongly advises against using any CBD or THC if you are pregnant or breastfeeding.
Use in Younger and Older Populations
Children and teenagers should not use CBD or THC unless under the supervision and recommendation of a healthcare provider.
Older adults should also check with a healthcare provider before using CBD or THC.
Potential for Interaction
Using CBD or cannabis alongside the following may result in adverse effects:
Drugs used for the treatment of bipolar disorder, such as lithium
Drugs used for the treatment of major depressive disorder (MDD), such as Prozac (fluoxetine)
Drugs that slow down the central nervous system (CNS), such as certain anxiety or sleeping medications
Side Effects of CBD vs. THC
CBD and THC carry the potential for side effects of varying severity.
However, know that CBD- and THC-related side effects may be determined by various factors, including the product strength and purity, quantity used, how it was used (for example, topical or oral), and other medications used.
The following outlines potential side effects associated with CBD vs. THC.
Common Side Effects of CBD
Common side effects associated with the use of CBD include:
Common Side Effects of THC
Common side effects associated with the use of THC include:
A "high"
Altered senses (such as seeing brighter colors) or sense of time
Mood changes
Impaired body movement
Problems with memory, thinking, and problem-solving
Hallucinations and delusions (with high doses of cannabis)
Psychosis (more likely when regularly using high-potency cannabis)
Long-Term Side Effects of THC
Long-term side effects associated with the use of THC (marijuana) include:
Breathing problems
Problems with brain development (impaired thinking, memory, and learning)
Worsening of symptoms in people with schizophrenia
Federal and State Guidelines: CBD vs. THC
As highlighted above, CBD is federally legal (legal throughout the United States) as long as it contains 0.3% or less THC.
However, foods and beverages that contain CBD are not technically considered legal on a federal scale. Every state has different laws surrounding CBD and THC.
For example, in some states, such as Connecticut, Colorado, and New Jersey, all cannabis products, including CBD and THC, are legal.
Other states have certain limitations.
Alternative Treatment Options for Anxiety
Beyond CBD or THC, if you are interested in treatment for anxiety, there are many options, including prescription medications, therapy, and non-medicinal measures such as:
Writing thoughts in a journal
Eating a healthy diet (including reducing or eliminating caffeine and alcohol)
Exercising (especially outdoors)
Using mindfulness techniques like deep breathing, meditation, yoga
Stopping smoking
Getting enough quality sleep
Using a weighted blanket
Sticking to a routine
Joining a support group
You can also ask your healthcare provider for other recommendations on how to treat your anxiety symptoms.
Summary
CBD (cannabidiol) is derived from hemp or non-hemp plants and contains 0.3% THC (the mind-altering component of cannabis) or less.
CBD alone does not have a mind-altering effect, while THC is believed to be responsible for producing the mind-altering effect of cannabis.
THC is the component of cannabis that gives the "high" effect.
Both CBD and THC are used for a variety of conditions, such as sleep and anxiety.
Before using CBD or THC, you should consult your healthcare provider to ensure that it is safe and appropriate for you to use.
Frequently Asked Questions
Is it possible to become addicted to cannabis?
Using cannabis can lead to cannabis use disorder (or marijuana use disorder), which can become addiction in severe cases. Up to 30% of people who use cannabis have some degree of cannabis use disorder.
People who start using marijuana before 18 years old are much more likely to develop cannabis use disorder.
People with cannabis use disorder have dependence, meaning that they feel withdrawal symptoms when not using cannabis.
This disorder becomes an addiction in individuals who cannot stop using cannabis, even though it interferes with their lives.
Is it possible to overdose on cannabis?
Using too much cannabis can cause more severe effects, such as significant confusion, anxiety, paranoia, fear or panic, a fast heart rate, hallucinations, delusions, high blood pressure, and nausea or vomiting. In some cases, injury could occur, such as a car crash, fall, or poisoning.
Consuming food or beverages that contain cannabis increases the risk of poisoning.
What are synthetic cannabinoids?
Synthetic cannabinoids—also referred to as synthetic cannabis, synthetic marijuana, spice, or K2—are manufactured chemicals that some people use as a cannabis alternative.
As "fake weed," synthetic cannabinoids should not be used because they can cause severe and toxic side effects, such as rapid heart rate, agitation, confusion, vomiting, and hallucinations, which may require emergency treatment and hospitalization.
Read the original article on Verywell Health.
