Antidepressants That Cause Weight Loss

Is your antidepressant why the numbers on the scale keep dropping?

Medically reviewed by Rachel Goldman, PhD, FTOS

While some antidepressants are linked to weight gain, others are associated with weight loss. Because depression can negatively impact your energy levels and motivation, taking antidepressants may also have the effect of giving you more energy once your depression starts to improve.

If you have depression, there's a solid chance your doctor or therapist will recommend therapy and/or antidepressant medications. Antidepressants can help you feel better, but they can also have side effects—which may include gaining or losing weight.

Like with most medications, individual results may vary. Any side effect—including weight-related side effects—depends entirely on how your body reacts to a medication. It is possible that you will notice no change in weight or that you will swing in the opposite direction of what's typical, no matter which medication you take. For some people, the fluctuation in weight is only temporary.

At a Glance

Depression and depression treatments can cause the numbers on the scale to vary, and some antidepressants have been linked to weight loss in some people. How you react to your treatment depends on many factors, including the symptoms of your condition, your body's response to the treatment, and any lifestyle changes you may make. Keep reading to learn more about antidepressants that cause weight loss and steps you can take to manage your weight while you are taking antidepressants.

Which Antidepressants Cause Weight Loss?

Weight changes are among the reported side effects of antidepressant drugs. It's natural to get really frustrated with this side effect. While everyone's response is different, there are some antidepressants that cause weight loss, while a few others have been linked to weight gain.

Antidepressants linked to weight loss include:

• Prozac (fluoxetine): One 2022 study found that adults who took 60 mg of Prozac each day lost an average of six pounds during their initial six months of treatment. This effect appears to be dosage dependent since people taking lower doses did not experience such weight loss effects.

• Wellbutrin (bupropion): Research has found that people taking Wellbutrin lost an average a little more than seven pounds over the course of two years of treatment.

• Effexor (venlafaxine): People who take Effexor may experience a quick loss of a small amount of weight, and in a 10-year-long study, Effexor was associated with below-average weight gain.
  

Takeaway

A link implies a statistical association, but that doesn't mean you'll be affected similarly. Put another way, these antidepressants are associated with weight loss, but they are not antidepressants that cause weight loss every time. You might lose weight, or you might not. For some people, these weight-loss effects fade after a few months of antidepressant use.

The specific type of medication you're taking (and how it affects your body) can play a part in determining the kind of weight-related changes you might experience.

Prozac is a selective serotonin reuptake inhibitor (SSRI). Effexor is a serotonin-norepinephrine reuptake inhibitor (SNRI). Wellbutrin is an atypical antidepressant that doesn't change serotonin levels in the brain. Rather, it uniquely alters other brain chemicals like noradrenaline and dopamine. This is associated not only with weight loss but also improved sexual functioning.

However, Wellbutrin may not be appropriate for everyone. This is especially true of people with a history of seizures or an eating disorder like anorexia or bulimia.

Like all antidepressants, Wellbutrin, Prozac, and Effexor carry a black box warning. This states their potential for increased risk of suicidal thoughts and actions in children, teens, and young adults during the early stages of treatment.

Takeaway

If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 988 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.

For more mental health resources, see our National Helpline Database.

Antidepressants and Weight Gain

While there are some antidepressants that cause weight loss, others are associated with weight gain. The hows and whys of this aren't quite clear. That's because weight gain while taking an antidepressant is complicated. Each person's situation is difference, and their response may vary.

There is some research investigating the interaction of brain chemicals, antidepressants, and hormones that might result in weight gain, but more study is needed.

Takeaway

One study found that about 65% of people taking antidepressants experienced weight gain. Another noted that weight gain can be a "significant cause" of discontinuing treatment in the first two months.

While the statistics suggest it's pretty common, it's important to remember that not all antidepressant medications have this side effect. If you are concerned about gaining weight, work with your doctor to determine which treatment options is the least likely to have weight-related side effects.

Research shows weight gain is mostly linked to a few antidepressants:

• Paxil (paroxetine) and Celexa (citalopram): Selective serotonin reuptake inhibitors (SSRIs)

• Elavil (amitriptyline): A tricyclic antidepressant

• Remeron (mirtazapine): An atypical antidepressant

• Nardil (phenelzine): A monoamine oxidase inhibitor (MAOI)
  

Weight gain associated with other antidepressants, if it does occur, is usually short-lived. In addition, individual factors seem to play a role. In other words, it's hard to predict who will gain weight on certain antidepressants because so many variables are at play.

Antidepressants That Don't Cause Weight Loss or Gain

Some antidepressants appear to be weight-neutral (they are not associated with weight gain or weight loss). These include Trintellix (vortioxetine), Manerix (moclobemide), Pristiq (desvenlafaxine), and trazodone.

Why Antidepressants Affect Weight

So what's the link between antidepressants and your weight? One reason there are antidepressants that cause weight loss or gain is that some of these medicines impact appetite pathways.

Antidepressants that cause weight loss may do so by causing your appetite to decrease. Those that cause weight gain may stimulate the appetite instead.

Remember, depression itself can also affect your activity levels, food choices, and sleep habits—all of which affect weight. It's hard to feel motivated to work out when your mood and energy levels are low. And when you're feeling sad, you might be more tempted to reach for sugary, high-fat, and processed snacks to get a quick dopamine hit.

So, as the medication begins to reduce feelings of depression, these behaviors can also change. As these behaviors change, you may find that you gain or lose weight.

Your family history may even impact whether your weight will change while taking an antidepressant. For instance, one study found that a family history of obesity helps predict weight gain when taking this type of drug.

Related: What to Do If You Gain Weight While Taking Antidepressants

Choosing an Antidepressant

Treating your depression is paramount to your mental health and well-being. Your physical appearance and health are also important. Have a candid discussion with your doctor about depression treatment, as there are a lot of options. In general, it is best to avoid making a decision based on weight-related side effects, as these can be unpredictable and also temporary.

Often, it is difficult to know which antidepressant will work best for you. It may take some trial and error to find a medication that is effective and also does not cause unmanageable side effects. Always discuss your treatment with your doctor (never stop taking your antidepressant without your doctor's go-ahead).

Related: How to Know Which Antidepressant Is Best for You

Tips When Taking Antidepressants That Cause Weight Loss

If you are worried about potential weight-related side effects, talk to your doctor about diet and exercise changes you can make as well. While there are antidepressants that cause weight loss, you can take steps and make lifestyle changes to help manage these side effects.

The strategies to manage your weight can also improve your emotional and mental health. Often, a combination of medication and a healthy lifestyle is the best treatment plan for depression.

Exercise

Whether you are hoping to lose weight, mitigate weight-related side effects from your antidepressant, maintain your weight, or gain weight, exercise can help. And you can start small. Walking, stretching, and moderate-intensity resistance training can all be helpful.

What's most important is consistency. Small but consistent changes can add up to big changes in your health.

The Physical Activity Guidelines for Americans suggest at least 150 to 300 minutes a week of moderate-intensity exercise for health benefits. That's 30 to 60 minutes, five days a week, of any exercise you enjoy, from bicycling to swimming to tennis to yoga.

Related: The Mental Health Benefits of Physical Exercise

Diet

If you are taking one of the antidepressants that cause weight loss, focus on eating a diet rich in whole foods, including fruits, vegetables, whole grains, lean proteins, and healthy fats.

Takeaway

Eating a well-balanced diet can help with weight management. It's also a great way to boost your mood, since there is a connection between diet and depression.

Try making small swaps and changes every few days or every week. If you typically drink fruit juice, for example, switch to water and whole fruits; you'll get less sugar and more satiating fiber this way. Another way to get more fiber is by choosing whole grains (such as whole-wheat bread) over refined grains.

Related: Foods to Help Fight Depression

Antidepressants As Weight Loss Aids

If you do not have depression, antidepressants are not recommended for weight loss. Taking these medications for that purpose has negligible results. There's no proof that it helps any more with losing weight than diet and exercise alone.

The use of antidepressants for weight loss is not approved by the Food and Drug Administration (FDA). While your doctor may not prescribe these medications for weight loss, they may consider the potential effects on weight when prescribing them to treat depression.

Some researchers suggest that doctors may want to take a weight-centric approach when choosing antidepressants. This may involve prescribing antidepressants that cause weight loss or that are weight-neutral rather than those associated with weight gain.

Takeaway

Can Prozac make you lose weight? Yes. But losing weight by eating nutritious foods and getting regular physical activity is recommended over trying a "Prozac weight loss diet."

If weight loss is your main concern, talk to your healthcare provider about the best way to work toward a weight-loss goal. There are some prescription medications approved for the treatment of obesity, including Contrave.

Contrave is a combination of bupropion (the active ingredient in the antidepressant Wellbutrin) and naltrexone (which is also used to treat some substance use disorders). Research has shown it to be fairly effective, well-tolerated, and safe. As with many medications used for weight loss, it's typically used in combination with a reduced-calorie diet and an exercise program.

Takeaway

Treating depression takes patience and resilience as you find the right plan, but it can be done. While antidepressants can cause weight loss or gain, you can take steps to optimize both your physical and mental health. Your efforts in one area will support the other.

Related: Do I Have to Take Antidepressants Forever?

Frequently Asked Questions

Which antidepressants give you energy and weight loss?

Wellbutrin (buproprion) is a stimulating antidepressant and it is also sometimes associated with weight loss. However, there is no guarantee that taking Wellbutrin will give you energy or cause weight loss.

One research review found that medications including Provigil (modafinil), flupenthixol, and Strattera (atomoxetine) helped improve symptoms of fatigue and low energy in people with depression. However, these are not antidepressant drugs.

Why am I losing weight on antidepressants?

Some antidepressants may be associated with weight loss, perhaps due to an effect on appetite or improved energy. But scientists are still working to understand why some people lose weight while taking antidepressants.

What is the best antidepressant if you are trying to lose weight?

It is more important for your antidepressant to treat symptoms of depression than to promote weight loss. If you are trying to lose weight and you also need to take an antidepressant, talk to your healthcare provider about the best antidepressant for you. You may be able to avoid antidepressants associated with weight gain in favor of one associated with weight loss, if it is appropriate for your specific needs.

What antidepressants make you lose your appetite?

Prozac (fluoxetine), Cymbalta (duloxetine), and Wellbutrin (buproprion) may affect appetite levels, particularly during the early months of use. However, every person's experience is different.

Is there an anti-anxiety medication that causes weight loss?

Antidepressants are often prescribed to treat anxiety. Other medications that are sometimes prescribed include SNRIs, atypical antidepressants, tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), and benzodiazepines. There is no specific anti-anxiety medication that causes weight loss.

Which antidepressants cause the least weight gain?

Three antidepressants that are less likely to cause weight gain are Wellbutrin (bupropion), Prozac (fluoxetine), and Effexor (venlafaxine).

Read the original article on Verywell Mind.