Adenomyosis vs. Endometriosis
Both affect the lining of the uterus, but have distinct differences
Medically reviewed by Cordelia Nwankwo, MD
Adenomyosis and endometriosis are medical conditions that cause an overgrowth of the lining of the uterus (endometrium). With adenomyosis, the tissue grows into the walls of the uterus. With endometriosis, the tissues grow outside of the uterus and can extend to the ovaries, fallopian tubes, pelvic wall, and bowel.
Although they are two distinct conditions, adenomyosis and endometriosis share symptoms such as painful periods and heavy menstrual bleeding. Because of this, they are often mistaken for one another. They can even occur at the same time.
This article describes the symptoms and causes of adenomyosis and endometriosis and explains how the two conditions are diagnosed and treated.
A Note on Gender and Sex Terminology
Verywell Health acknowledges that sex and gender are related concepts, but they are not the same.
Sex refers to biology: chromosomal makeup, hormones, and anatomy. People are most often assigned male or female at birth based on their external anatomy; some people do not fit into that sex binary and are intersex.
Gender describes a person's internal sense of self as a woman, man, nonbinary person, or another gender, and the associated social and cultural ideas about roles, behaviors, expressions, and characteristics.
Research studies sometimes don't use the terminology in this way. For example, terms that describe gender (“woman,” “man”) may be used when terms for sex (“female,” “male”) are more appropriate.
To reflect our sources accurately, this article uses terms like "female," "male," "woman," and "man" as the sources use them.
Tissue Growth in Adenomyosis vs. Endometriosis
Adenomyosis involves cells of the endometrium extending into the walls of the uterus (myometrium), causing them to thicken.
Despite these changes, the endometrial tissues remain functional and are shed with each period, causing bleeding.
The tissues that extend beyond the uterus in endometriosis are different. While they are similar to endometrial tissue, they are not exactly like what's in the uterus.
These tissues function similarly—breaking down and bleeding with each period—but ultimately become trapped in the organs they invade. This can lead to scarring and adhesions (the sticking together of tissues).
Symptoms of Adenomyosis and Endometriosis
Despite being two separate conditions, adenomyosis and endometriosis share many of the same symptoms, including heavy menstrual bleeding and painful periods. Even so, there are certain signs that can help differentiate them.
Adenomyosis Symptoms
Heavy menstrual bleeding
Painful menstrual periods
Painful sexual intercourse
Enlarged uterus
Endometriosis Symptoms
Heavy menstrual bleeding
Painful menstrual periods
Painful sexual intercourse
Spotting or bleeding between periods
Infertility
Pain with bowel movements or urination
Digestive problems
Fatigue
Comparatively, though, endometriosis causes more symptoms than adenomyosis. In some cases, people with adenomyosis may have no symptoms at all and only find out about their condition when it is advanced or diagnosed along with endometriosis.
Learn More: How to Manage Endometriosis Pain
Causes
The exact cause of adenomyosis and endometriosis is unknown. However, certain risk factors can increase the likelihood of developing these conditions.
Broadly speaking, adenomyosis is associated with prior or ongoing stress placed on the uterus. Endometriosis is influenced by genetics and other conditions that interfere with normal menstrual cycles.
Around 10% of females of reproductive age are affected by endometriosis. While it is harder to determine the prevalence of adenomyosis because it is often asymptomatic, studies suggest that the condition may affect about 20% of females of reproductive age.
Additionally, rates of endometriosis in transgender men are higher than those experienced by cisgender females and need to be considered.
Adenomyosis Risk Factors
Being in your 40s or 50s
Having multiple pregnancies
Prior uterine surgery
Smoking
A prior ectopic pregnancy
Tamoxifen use
Endometriosis Risk Factors
Being in your 30s or 40s
Having never had children
Having short menstrual cycles (less than 27 days)
Heavy menstrual periods that last for more than seven days
A family history of endometriosis
Menstruation starting before age 11
Learn More: How Do Endometriosis Symptoms Feel?
Diagnosing Adenomyosis vs. Endometriosis
Adenomyosis and endometriosis are diagnosed with many of the same tools and techniques, including:
Pelvic exam: A manual examination of the pelvis organ
Transvaginal ultrasound (TVUS): A wand-like device inserted into the vagina that can image pelvic organs with reflected sound waves
Magnetic resonance imaging (MRI): A imaging technology that uses powerful radio and magnetic waves to create highly detailed images of soft tissues
There are also other diagnostic tools used specifically for adenomyosis or endometriosis.
Identifying Adenomyosis
The only way to truly diagnose adenomyosis is to examine the tissue of the uterus after a hysterectomy, surgery to remove the uterus. The decision to undergo a hysterectomy is based on a review of the benefits and risks of the procedure.
In some instances, your healthcare provider may perform a biopsy to obtain a sample of the endometrium that can be examined under a microscope. But this is done to ensure that a more serious condition like uterine cancer or endometrial cancer isn't involved—not to aid in the diagnosis of adenomyosis.
Identifying Endometriosis
In some cases, your healthcare provider will refer you to a surgeon to undergo a laparoscopy. This is a surgical procedure in which a tube-like scope is inserted through a tiny incision in the abdomen to view the pelvic organs.
Laparoscopy can provide details about the size, location, and extent of the spread of endometrial tissues outside of the uterus. Your surgeon may also take an endometrial biopsy for further testing.
Learn More: How Endometriosis Is Treated
Treatment Options
Treatment for adenomyosis and endometriosis varies based on which symptoms are present and how severe they are. While there is no cure for these conditions, they can be well-managed.
Among some of the treatment options commonly used for both conditions are:
Nonsteroidal anti-inflammatory drugs (NSAIDs): These include over-the-counter drugs like Advil (ibuprofen) to relieve pain associated with heavy menstrual bleeding.
Hormonal birth control: These include a progestin-only intrauterine device (IUD) or continuous-use birth control pills to halt menstruation and relieve pain.
Hysterectomy: Surgery may be explored when conservative therapies fail to provide relief.
Other treatments used specifically for endometriosis include:
Gonadotropin-releasing hormone (GnRH) agonists: These drugs stop menstruation and, by doing so, reduce severe menstrual pain.
Aromatase inhibitors: These are drugs that reduce the amount of estrogen in your body. They are commonly prescribed alongside a hormonal contraceptive.
Laparoscopic surgery: This is a conservative alternative to hysterectomy that selectively removes tissue overgrowth where it occurs.
Fertility treatment: This includes in vitro fertilization (IVF) if endometriosis causes infertility.
Learn More: Adenomyosis and Hysterectomy
Living With Adenomyosis or Endometriosis
Living with chronic pain from adenomyosis or endometriosis can be distressing and lead to feelings of depression or anxiety. If you are concerned about your mood, ask your healthcare provider for a referral to a mental health professional such as a psychologist or therapist.
A 2016 study reported that women with endometriosis found it helpful to plan work and social events around their menstrual periods. This is to avoid being active during the heaviest days of their periods, when pain is the most intense.
Other coping techniques for endometriosis include:
Routine exercise
Massage
Heating pad application
Summary
Adenomyosis and endometriosis are chronic conditions that affect the endometrium, the tissue lining of the uterus. They differ in that the former involves tissue growth into the muscular wall of the uterus, while the latter involves tissue growth outside of the uterus into surrounding organs.
Symptoms of both include pelvic pain and heavy menstrual periods, but there are some unique symptoms as well. Possible treatments include over-the-counter pain relievers, hormonal contraceptives, and hysterectomy.
Frequently Asked Questions
Is adenomyosis more severe than endometriosis?
Endometriosis is more likely to cause symptoms than adenomyosis. Many individuals with adenomyosis do not know they have it because of the lack of symptoms.
Does adenomyosis cause abdominal distension?
Adenomyosis may lead to abdominal distention. The uterus can become enlarged when its walls become overly thick due to endometrial tissue growth. This can cause the abdomen to swell.
Can adenomyosis turn to endometriosis?
While adenomyosis does not cause endometriosis, the two conditions are linked. Individuals with endometriosis are more likely to be diagnosed with adenomyosis than women without a disorder of the endometrium.
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