The 17 Best Acne Spot Treatments That Zap Pimples, According to Dermatologists
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Updated March 14, 2024: This article on the best acne spot treatments was updated with reporting on the news about Valisure’s report on benzoyl peroxide in acne products. We consulted with a board-certified dermatologist for information on what this means for acne sufferers, and refresh our product selections with editor-tested picks. Our editors are currently testing acne products from brands like La Roche-Posay and Paula’s Choice for consideration in this expert-approved guide.
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When breakouts pop up out of nowhere at the most inopportune times, your best bet at damage control is selecting one of the best acne spot treatments in your beauty wardrobe. Acne spot treatments come in gels, lotions, creams, liquids, and the very popular pimple patches. This variety means that all skin types can reap the benefits, especially those with dry or sensitive skin types that typically can’t tolerate drying acne-fighting ingredients slathered all over the face.
Acne treatments have been in the news following a Valisure report that cited elevated levels of benzene in benzoyl peroxide acne products from brands like Proactiv, Cerave, Clinique, and Clearasil. Benzene is classified as carcinogenic to humans by the Department of Health and Human Services, causing alarm for acne sufferers who rely on the ingredient.
“Generally benzoyl peroxide is considered a safe product, unless you are storing these agents in hot places or using them for long periods of time after storage, in general [it] should not be a problem,” says board-certified dermatologist Dr. Paul Jarrod Frank. “Certainly until further information is found, stay away from the products that are on the list, we should also always realize that we have to take care of our products and follow the instructions for storage.”
The good news: There are plenty of clean formulas available that rely on ingredients other than benzoyl peroxide, including options that enlist naturally-derived witch hazel or willow bark to zap acne.
“In this day and age, there are more acne spot treatment formulas on the market than ever before,” says board-certified dermatologist Dr. Geeta Yadav. “However, the format remains largely the same topical spot treatments — with the more recent inclusion of pimple patches.”
The most effective acne spot treatment for you depends on the type of breakout you’re experiencing. Board-certified dermatologist Dr. Brooke Jeffy explains, “If your pimple is raised or has visible pus, reach for a non-medicated hydrocolloid patch, which will help drain and flatten by drawing out excess oil and fluid. ”While acne spot treatments are amazing for tackling a pesky pimple, those with consistent breakouts should build an acne-fighting skin care and makeup regimen. A full routine can include items like acne-fighting cleansers, moisturizers, face serums, retinols, acne-fighting SPFs, foundations, and even unexpected items like pillowcases that can help minimize bacteria (just remember to wash them regularly).
Spot treatments are usually at higher concentrations than traditional acne serums because they’re intended to work incredibly fast — some even as quickly as a few hours — on a targeted pimple or area. The powerhouse ingredients usually incorporated into these fast-acting treatments are actives like salicylic acid, witch hazel, and tea tree oil. They work by drying out excess oils and reducing inflammation to minimize the size and redness of the acne breakout.
We’ve created a comprehensive list of some of the best acne spot treatments available through the use of customer reviews, expert recommendations, bestsellers, and a thorough round of product testing. Below you’ll find the 15 best acne spot treatments, tailored for specific needs.
Top Acne Spot Treatments of 2024
Editors’ Choice: Mario Badescu Drying Lotion
Editors’ Choice: Differin Acne Retinoid Treatment Gel
Editors’ Choice: Burt’s Bees Herbal Blemish Spot Treatment Stick
Best Patches: Hero Cosmetics Mighty Patch
Best for Dry Skin: Skinfix Acne + 2% BHA and Azelaic Acid Acne Spot Treatment
Best for Oily Skin: Bliss Clear Genius Acne Spot Treatment
Best Lotion: Neutrogena Stubborn Acne Spot Drying Lotion
Best Liquid: Kiehl’s Truly Targeted Acne Clearing Solution
Best Fast-Acting: Murad Rapid Relief Acne Spot Treatment
Best Sulfur: Kate Somerville EradiKate Acne Spot Treatment
Best for Cystic Acne: Yon-Ka Paris Skincare SOS Spot Blemish Treatment
Best for Sensitive Skin: Rael Miracle Clear Soothing Spot Gel
Best Splurge: Valmont Primary Solution Targeted Blemish Treatment
Editor’s Choice: Top Acne Spot Treatments of 2024
The right acne treatment for you depends on the type of breakout you’re experiencing — the acne spot treatment that works best for cystic acne may not be the best fix for blackheads. On top of this, certain skin types do better with gel formulas versus lotions. Personal preference comes into the mix as well, as some may want a spot treatment to wear during the day, where others prefer to apply the formulas overnight. And of course, the recent news of benzene found in certain acne products may also have you looking for a treatment that relies on natural ingredients. Instead of selecting one best overall acne treatment, we’re spotlighting the below three acne treatments after thorough testing and expert input.
Differin Acne Retinoid Treatment Gel: Our testers — and many dermatologists — rate Differin’s formula as the best drugstore acne spot treatment on the market. The formula used to be only available by prescription, but now you can purchase it over the counter. Its clinical-grade adapalene is a type of retinol that exfoliates skin and promotes turnover for clearer skin.
Mario Badescu Drying Lotion: To zap a pimple overnight, go with Mario Badescu’s legendary drying lotion that we rate as the best overnight acne spot treatment. All you have to do is drop a cotton swab into the container and apply directly on problem areas — the sulfur and alcohol work together to dry out excess oils and clear away bacteria.
Burt’s Bees Herbal Blemish Spot Treatment Stick: Those looking for an acne spot treatment with naturally-derived ingredients should opt for Burt’s Bees spot treatment stick, according to our testers. It contains willow bark (considered a plant-based alternative to salicylic acid) and tea tree oil to clear the skin, plus cica to calm it.
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EDITORS' CHOICE
Differin Acne Retinoid Treatment Gel
Type: Gel
Size: 1.6 oz
Key Ingredients: Adapalene
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Target Top-Quality Store Badge on Google: 4.6/5 stars
$14.49
$16.19
The best thing Differin ever did was release an OTC version of its formerly prescription-only acne treatment — this formula is the best drugstore acne spot treatment you can find. Adapalene, the powerhouse ingredient in this acne spot treatment, is well-known for its acne-fighting properties. Differin targets two main causes of breakouts: clogged pores and inflammation. In addition to that, it also helps to speed up skin cell turnover to reveal a smoother complexion over time. While this is a great product, it’s a retinol product, and certain precautions need to be taken. It’s best to use it once a day after cleansing, preferably at night. Retinoids can cause sensitivity, so limiting sun exposure will go a long way and always using sunscreen outside is a must.
Editor testing and review notes: “When I’m stressed out, my skin follows suit with sporadic breakouts that can last for weeks at a time. Differin is one of the few acne spot treatments that I know I can rely on to lessen the look of pimples and blackheads — although you can dab it directly on a zit, I find that the best results come when I apply a thin layer on my complexion before night cream. My skin is prone to redness, but this formula doesn’t irritate it.”
Price upon publish date of this article: $14.49
EDITORS'S CHOICE
Mario Badescu Drying Lotion
Type: Lotion
Size: 1 oz.
Key Ingredients: Salicylic acid, sulfur, calamine, and zinc oxide
Ulta Top-Quality Store Badge on Google: 4.8/5 stars
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Sephora Top-Quality Store Badge on Google: 4.8/5 stars
$16.15
$17
$17
This formula was created in the 1960s by Mario Badescu and is still a top-seller today. “I like Mario Badescu Drying Lotion,” says Dr. Yadav. “It’s a classic formula that uses sulfur and salicylic acid to help treat a blemish overnight.” A clarifying, bi-phase solution, this best dermatologist-recommended acne spot treatment dries up blemishes by drawing out acne-causing debris while reducing the inflammation of these breakouts the next day. Without shaking the bottle, dip a cotton swab into the pink sediment and dab directly onto your breakout. Let the formula dry on its own without rubbing it into the skin. Then go to sleep and rinse off well with water the next morning.
Editor testing and review notes: “This little vial is always on my bathroom counter with some clean cotton swabs. Yes, it’s excellent when I’m trying to swat down a pimple that’s already surfaced, but I also notice improvement with cystic acne around my time of the month if I apply it on the problem area nightly. I have dry skin, so sometimes the skin around my pimple will peel the day after application, but it’s easy to slough away with a gentle exfoliator.”
Price upon publish date of this article: $16.15
EDITORS' CHOICE
Burt’s Bees Herbal Blemish Spot Treatment Stick
Type: Oil
Size: 0.2 oz.
Key Ingredients: Willow bark extract, cica, and tea tree oil
Ulta Top-Quality Store Badge on Google: 4.8/5 stars
Target Top-Quality Store Badge on Google: 4.6/5 stars
Walmart Top-Quality Store Badge on Google: 4.5/5 stars
$7.99
$7.84
This convenient Burt’s Bees acne spot treatment is formulated with willow bark extract, making it one of the best clean acne spot treatments you can buy. This ingredient naturally contains BHAs to reduce acne and unclog pores that lead to breakouts. The best part is that neither cica nor the tea tree oil (an herbal astringent) are abrasive. Packed in an easy-to-use roll-on stick, this product gently soothes the skin as well.
Editor testing and review notes: “Traveling comes with plenty of acne triggers for my skin — greasy food, hard water in hotels, cotton pillowcases instead of my trusted silk one at home, and perhaps a glass or two of wine. That’s why I keep this Burt’s Bees herbal acne spot treatment in my travel bag wherever I go — it’s a tiny roll-on that does its work gently, never leaving my skin irritated, flaky, or inflamed. After two nights of consistent use, I notice a major improvement in breakouts.”
Price upon publish date of this article: $7.84
BEST PIMPLE CREAM FOR OILY SKIN
Bliss Clear Genius Acne Spot Treatment
Type: Gel
Size: 0.5 fl oz
Key Ingredients: 2% salicylic acid, witch hazel, niacinamide, zinc PCA, and cica.
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Walmart Top-Quality Store Badge on Google: 4.5/5 stars
$12.90 $15 14% off
Salicylic acid is a recurring ingredient in many of the acne spot treatments on this list for a reason. While this fragrance-free formula is great for all skin types, it works especially well on oily skin. Using a gentle yet effective cocktail of salicylic acid, witch hazel, niacinamide, zinc PCA, and cica this spot treatment helps fight pimples and blackheads without stripping the skin. On clean skin, apply to the affected area using a thin layer one to three times a day.
What testers say: “It does work on the whiteheads on my sensitive skin but only in places that get a lot of air to dry out. Sometimes,it takes as long as 3-5 days to dry one out, though. Gentle, not fast. Cruelty-free, though!”
Price upon publish date of this article: $12.90
BEST ACNE SPOT TREATMENT FOR SENSITIVE SKIN
Rael Miracle Clear Soothing Spot Gel
Type: Gel
Size: .14 fl. oz.
Key Ingredients: Succinic acid, cica, tea tree oil
Ulta Top-Quality Store Badge on Google: 4.8/5 stars
$11.99 $14.99 20% off
One of the easiest ways to self-sabotage when clearing a breakout is to use unclean application methods like not washing your hands or face before. Rael spot treatment comes in an easy-to-apply hygienic applicator with a silicone brush, but it must be noted that upon first use that it might take close to 50 clicks to actually dispense the product. Heavy hitters include succinic acid which reduces blemishes, inflammation and unclogs pores while also acting as a restorative agent for the skin’s pH. Cica aids in reducing redness while tea tree helps with inflammation as well.
What testers say: “I have used Rael’s spots and those are great, but this works better for me. The spots keep the area moist and this allows them to dry out. I tend to break out after epilation of my facial peach fuzz. This allows me to only have two days of spots vs. a week.”
Price upon publish date of this article: $11.99
BEST ACNE SPOT TREATMENT PATCHES
Hero Cosmetics Mighty Patch
Type: Patches
Size: 36 Count
Key Ingredients: Hydrocolloid
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Ulta Top-Quality Store Badge on Google: 4.8/5 stars
$10.77
$12.99
While gels and creams have reigned supreme in the way of traditional acne spot treatments, hydrocolloid pimple patches have become fast favorites over the last couple of years with Hero Cosmetics leading the charge. These seamless, easy-to-apply patches work best on white-heads and to bring debris to a head while drying out excess moisture, and this brand is a favorite of Jeffy’s. “They work to reduce inflammation, deliver treatments, and also help by deterring picking,” she explains.
What testers say: “Mighty Patch Original patches have duct tape-caliber sticking power. I have dry skin, so I’m always layering on face serums and moisturizers before bed — these stickers stay put, even on top of those skin care products. They’re peerless for purging whiteheads.”
Price upon publish date of this article: $10.77
BEST ACNE SPOT TREATMENT FOR DRY SKIN
Skinfix Acne + 2% BHA and Azelaic Acid Acne Spot Treatment
Type: Lotion
Size: 0.5 oz
Key Ingredients: Salicylic acid, azelaic acid, kaolin clay, and niacinamide
Sephora Top-Quality Store Badge on Google: 4.8/5 stars
Walmart Top-Quality Store Badge on Google: 4.5/5 stars
$30
This highly rated Skinfix acne spot treatment contains salicylic acid to help decongest clogged pores while also eliminating excess oil. Niacinamide, an ingredient that’s well tolerated by and beneficial for many skin types, helps to minimize the look of pores and regulate sebum to create a balance to the skin. But even when acne disappears, post-acne hyperpigmentation often remains, which is why azelaic acid comes in handy for fading these marks and improving the look of uneven skin tone. Some reviewers have noted that this spot cream can be a little potent so it’s best to follow the user instructions and only apply to affected areas on the face or body after cleansing one to two times daily.
What testers say: “My face broke out so bad before an event and this cleared up my pimples overnight! It dried out the pimples and also helped with shrinking the size and decreased redness! Defs recommend!”
Price upon publish date of this article: $22
The Inkey List Succinic Acid Acne Treatment
Type: Cream
Size: 0.5 oz
Key Ingredients: Succinic acid, sulfur powder, salicylic acid
Sephora Top-Quality Store Badge on Google: 4.8/5 stars
$14
When you wake up with a pimple but have somewhere to be, you need an acne spot treatment that’ll layer comfortably under makeup. That’s what The Inkey List’s Succinic Acid Acne Treatment brings to the table. This formulas contains succinic acid, which has antibacterial properties to address the root cause of acne, plus salicylic acid and sulfur powder that sop up excess oil and release pore-clogging dead skin cells. The formula has a light green tint to it that helps color correct redness on fair skin types, too.
What testers say: “I absolutely love this treatment from Inky list. I’m on my fourth bottle and I have not strayed. Honestly, I’m used to having spot treatments absolutely dry out my skin, however; I have not had that experience with this product. I use it around once a day when I have acne and it even helps with reducing dark spots. The biggest bonus is that it’s super affordable!”
Price upon publish date of this article: $14
Thayers Rapid Acne Spot Treatment
Type: Lotion
Size: 0.5 oz
Key Ingredients: Sulfur, niacinamide, glycolic acid
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Ulta Top-Quality Store Badge on Google: 4.8/5 stars
$14.99
$14.99
Thayers is known for their witch hazel-based toners and lotions that fit squarely in an acne-fighting skin care routine. While lesser known, the brand’s acne spot treatment is a leading affordable spot treatment for its ability to soothe skin while banishing breakouts. Sulfur and niacinamide are the key ingredients in the formula, de-gunking pores without stripping or drying out the skin. For sensitive skin types that deal with acne, this top acne spot treatment is a great choice for its inclusion of calming ingredients like aloe vera.
What testers say: “This is like magic in a tube. I hit this on a blemish and the next morning it has significantly reduced in size or completely gone away!!! Highly recommend for those stubborn breakouts.”
Price upon publish date of this article: $14.99
BEST SPOT TREATMENT FOR HORMONAL ACNE
Neutrogena Stubborn Acne Spot Drying Lotion
Type: Lotion
Size: 1 oz
Key Ingredients: 10% sulfur, 4% niacinamide
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Walmart Top-Quality Store Badge on Google: 4.5/5 stars
$12.75 $14.97 15% off
$14.23
Using the maximum amount of sulfur available OTC, this spot lotion packs a punch. This tried and true ingredient penetrates the pores to clear out acne-causing buildup and bacteria while niacinamide works to clear dark spots left from acne over time. On clean skin, cover the entire pimple with a thin layer of this solution one to three times a day. Since sulfur is known to be drying, it’s best to start out once a day and build up use if your skin can tolerate it.
What testers say: “This does work well and will dry your pimples up after using consistently for a few days. You better keep your face really still though after applying it, because it starts to flake and peel off a bit as it dries.”
Price upon publish date of this article: $12.75
Indie Lee Banish Stick
Type: Gel
Size: 0.34 oz
Key Ingredients: Witch hazel, salicylic acid derived from wintergreen, burdock root extract
Ulta Top-Quality Store Badge on Google: 4.8/5 stars
Nordstrom Top-Quality Store Badge on Google: 4.8/5 stars
$16
$16
For a natural spot treatment, look to Indie Lee’s Banish Stick. This formula taps into the power of plants to zap zits and clear pores, with wintergreen-derived salicylic acid, witch hazel, and burdock root extract. All together, these ingredients help exfoliate away dead skin cells while reducing oil, effectively eradicating two of the most common causes of breakouts. Dry and sensitive skin types will appreciate that Indie Lee’s spot treatment also incorporates burdock root and Tasmanian pepper fruit, which nourish the skin.
What testers say: “Purchased this hoping it would help with my overproduction of sebum. I get a lot of acne on my chin, cheeks and upper neck. I have been using for just under a week and I am already noticing less clogged pores, skin colored bumps and drying up of the existing red, bumps that I had. There is no over drying of my skin or redness, the application is supper easy and I’m so happy with the results. I have been applying morning and night as a spot treatment on the existing red acne and as full surface treatment of the areas with the skin colored, clogged pores. Would definitely buy again!”
Price upon publish date of this article: $16
Caudalie Vinopure Color Correcting Spot Solution
Type: Cream
Size: 0.5 oz
Key Ingredients: Salicylic acid, tea tree, niacinamide
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Sephora Top-Quality Store Badge on Google: 4.8/5 stars
$25
$25
Caudalie’s Color Correcting Spot Solution is another acne spot treatment that you can comfortably wear during the day with other skin care products or under makeup. The formula is great for normal to dry skin types that deal with acne, as it doesn’t overly dry out skin while eradicating excess oils and dead skin cells that can cause or worsen breakouts. What’s more, this acne spot treatment also contains niacinamide that targets post-breakout scars and marks.
What testers say: “First off, this is the most luxurious feeling salicylic spot product I have ever owned. I have a bevy of glycolic acid serums, retinoids, etc., and while they are very effective, they also all have a bit of a funky smell which is usually par for the course for these things. I also own the Caudalie Vinoperfect serum and their facial spray, which smell divine and have a great texture, so it was no surprise that even a spot cream from them would feel like a luxury product.”
Price upon publish date of this article: $25
BEST LIQUID ACNE SPOT TREATMENT
Kiehl’s Truly Targeted Acne Clearing Solution
Type: Serum
Size: 0.5 fl. oz.
Key Ingredients: Salicylic acid, niacinamide, licorice root
Sephora Top-Quality Store Badge on Google: 4.8/5 stars
$30
This isn’t what many of us are used to when we think of a pimple patch, but Kiehl’s liquid patch, formulated with salicylic acid, creates a lightweight barrier on the skin while treating the breakout with the acne-fighting active. Great for combination, oily, and dry skin types, this treatment can be applied in the morning or evening and reduces pimple size in as little as 24 hours. And with regular use, it can fade acne marks in four weeks. To use, apply one drop to a clean fingertip after cleansing and gently dab it onto the breakout. Spread it into a thin layer without over-rubbing it. Then — the most important part — let the serum dry fully for 30 to 60 seconds before applying any SPF or makeup.
Editor testing and review notes: “Not only do I use this Kiehl’s spot treatment to target active breakouts — I also use it as an acne serum the days after my breakouts have calmed down to ensure they don’t leave a pesky mark in their wake. It’s a super lightweight formula that feels cooling on contact (a godsend when the breakout feels hot and irritated).”
Price upon publish date of this article: $30
BEST FAST-ACTING ZIT TREATMENT
Murad Rapid Relief Acne Spot Treatment
Type: Gel
Size: 0.5 oz.
Key Ingredients: Salicylic acid, witch hazel, and oat extract (to soothe)
Sephora Top-Quality Store Badge on Google: 4.8/5 stars
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
$26
$23.40
For all of the oily-skin readers out there, this is a great spot treatment for you to try out, but it is potent. It actually reduces the size of breakouts within four hours. While salicylic acid does what it does best to unclog pores, this treatment is infused with soothing oat extract and topped off with witch hazel to get rid of unwanted oil and tighten pores.
What testers say: “Smells like rubbing alcohol but works like a dream. It gets rid of incoming pimples and milia. If I feel a pimple coming in, I put this on and it’s gone overnight. For best results put it on, let it dry, put a pimple patch on overnight.”
Price upon publish date of this article: $23.40
BEST SULFUR ACNE SPOT TREATMENT
Kate Somerville EradiKate Acne Spot Treatment
Type: Mask
Size: 1 oz
Key Ingredients: 10% sulfur, BHAs, zinc oxide
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Sephora Top-Quality Store Badge on Google: 4.8/5 stars
Ulta Top-Quality Store Badge on Google: 4.8/5 stars
$25.20
$28
$28
Dr. Jeffy touts the use of sulfur as a “great spot-treating active” because it aids in the removal of excess oil while soothing inflammation without causing too much irritation. However, this fast-acting treatment is formulated with the maximum amount of sulfur (which can be drying) to fight existing breakouts while preventing new ones. So have a great moisturizer for acne-prone skin on hand. For application, don’t shake the bottle. Instead, dip a clean cotton swab into the pink sediment at the bottom of the jar and apply to your pimple. Allow the product to dry and either rinse off after an hour or leave on overnight.
What testers say: “Very effective at drying, but careful not to use multiple days in a row, for me that led to a dry patch.”
Price upon publish date of this article: $25.20
BEST SPOT TREATMENTS FOR CYSTIC ACNE
Yon-Ka Paris Skincare SOS Spot Blemish Treatment
Type: Liquid roll-on
Size: 15 mL
Key Ingredients: Ichtyol (a sulfur-rich mineral), bisabolol (an anti-inflammatory), lactic acid, and lime and quintessence (lavender, thyme, rosemary, cypress, geranium).
Skinstore Top-Quality Store Badge on Google: 4.4/5 stars
Amazon Top-Quality Store Badge on Google: 4.5/5 stars
Dermstore Top-Quality Store Badge on Google: 4.4/5 stars
$34.20
If you’re not a fan of heavy creams and lotions as spot treatments, this lightweight targeted acne treatment is an instant “add to cart.” Lactic acid, bisabolol, an anti-inflammatory, and lime help to regulate sebum production, reduce redness, and speed up cell turnover while calendula works to soothe compromised skin. While some spot treatments are best at targeting white heads or pustules, testers have noticed that this treatment also seems to keep stubborn cystic acne at bay. After cleansing and toning the skin, apply the roller ball to affected areas of your face in the morning and evening. With its easy travel-friendly packaging, you can also keep it in your purse to be applied throughout the day if necessary.
What testers say: “I was really surprised about how effective this treatment roller is! For something so small, it packs quite the punch. I have hormonal cystic breakouts and these help get them under control much faster than other products I’ve used. The applicator is also so unique and helps put the perfect amount of spot treatment on.”
Price upon publish date of this article: $30.40
BEST SPLURGE ACNE SPOT TREATMENT
Valmont Primary Solution Targeted Blemish Treatment
Type: Serum
Size: 20mL
Key Ingredients: Prebiotics, probiotics, borage oil
Saks Fifth Avenue Top-Quality Store Badge on Google: 4/5 stars
Neiman Marcus Top-Quality Store Badge on Google: 4.5/5 stars
$220
$220
For those who want a spot treatment infused with a bit of luxury, look no further than Valmont. This product’s aim is to aid in any skin emergency. This serum helps minimize the appearance of pimples, flakes and small lesions due to unbalanced skin. Pre- and probiotics help maintain and fortify a healthy skin ecosystem, while lightweight, fast-absorbing borage oil tackles inflammation. This serum is gentle enough for use in the morning and evening — all you need to do is apply to affected areas.
Price upon publish date of this article: $220
What to Know About Benzene Levels in Acne Treatments
On March 6, 2024, independent lab Valisure published a report citing elevated levels of benzene in benzoyl peroxide acne products from brands like Cerave, Clearasil, Proactiv, and more. Benzene is classified as a class 1 solvent by the Food and Drug Administration, meaning it’s a known human carcinogen or a strongly suspected human carcinogen.
Valisure has flagged benzene in dry shampoos, sunscreens, and deodorants, but those reports point to contamination of the products. The difference with benzene found in acne treatments is that rather than product contamination, benzene is the result of benzoyl peroxide breaking down due to factors like poor storage or product expiration.
“Benzoyl peroxide is considered generally safe at appropriate dosages by the FDA and has been deemed eligible to be over the counter for a long time, but when exposed to high temperatures for extensive periods of time benzoyl peroxide can turn into benzene, which is a very well known carcinogen that can cause various problems and various types of cancers,” explains Dr. Frank.
Should this be a cause for concern? “Well, yes and no,” says Dr. Frank. His advice is to store your products in a cool place and make sure you’re not using them after long periods of time after storage.
“Generally, you want to keep products in a cool place and in general, we want to keep as many chemicals, as a whole, off of our skin and out of our body,” says Dr. Frank. “There are always more natural ways to supplement how we treat acne or avoid the sun or things of that nature; you can’t rely too much on just using chemicals because anything that has the potential for benefit has the potential for adverse reactions, too.”
Dr. Frank notes that “even without the production of carcinogens, benzoyl peroxide along with other acne ingredients can cause irritation, sun sensitivity, and other medical and aesthetic issues, plus there are a lot of other options for people that are sensitive to benzoyl peroxide or are worried about the concern of increased benzene levels.” He notes that salicylic acid, oral medications, and lasers and light sources are options for those who want to minimize chemical exposure while treating their acne.
“For now, I would avoid the products listed until further data comes out, but I wouldn’t give up on benzoyl peroxide or other over-the-counter beauty products that have been around for a while either,” Dr. Frank says.
What to Look For in the Best Acne Spot Treatments
With everything on the market, finding the best acne spot treatment can easily become overwhelming. To break things down in a digestible way while shopping, reviewing the product’s ingredients, delivery, and formula to help you make a more informed decision.
Active ingredients: Ingredients matter when looking for an effective acne spot treatment (more on this next). Benzoyl peroxide, a popular ingredient kills acne causing bacteria, is best used on pus-filled pimples while salicylic acid, another popular ingredient, is an exfoliant that unclogs pores. This makes it great for zapping blackheads and whiteheads. Additionally, sulfur also addresses clogged pores but by targeting excess sebum and dead skin cells making it ideal for oily or congested skin types.
Delivery: Lotions, creams, gels and patches are all common methods of delivering acne-fighting actives in spot treatments. Dr. Jeffy notes that if your “pimple is raised or has visible pus,” a non-medicated hydrocolloid patch will help best. Gels or lotions might work best when trying to unclog pores and kill bacteria.
Formula type: Dr. Jeffy cautions that “spot treatments contain highly concentrated amounts of actives safe for use on small areas only,” meaning that formula type is important to consider especially for sensitive and dry skin types. Treatments with high concentrations of sulfur will be incredibly drying as might those with higher percentages of benzoyl peroxide and salicylic acid — so it’s important to factor in formulas with lower percentages of actives and those that are coupled with soothing ingredients or hydrators like niacinamide, calendula, and glycerin.
Top Acne-Fighting Ingredients in Acne Spot Treatments
Focusing on ingredients is key to an effective spot treatment because not every ingredient will treat every type of acne breakout. The reason so many acne spot treatments contain multiple actives is because each one will accomplish a different goal to help you reclaim clear skin. Here are some key players.
Salicylic acid: Salicylic acid is an exfoliant that goes deep into the pores making it great for whiteheads and blackheads. “Salicylic acid works by unclogging pores of excess oil and dead skin cells,” explains Dr. Jeffy.
Retinoids and adapalene: These vitamin A derivatives have been used in many prescription acne treatments and “have historically been used for treating more advanced acne,” says Dr. Yadav. They help to jumpstart skin cell turnover to relieve you of a breakout faster. However, they’re also known for not being the kindest to sensitive skin types.
Sulfur: “Sulfur targets both dead skin cells and sebum, two of the main factors that cause pore congestion,” says Dr. Yadav. Note that this ingredient can be drying, so you’ll want to keep a rich moisturizer in rotation when using the ingredient.
Niacinamide: “Niacinamide and sulfur are also great spot-treating actives that help remove excessive oil and soothe inflammation without irritation,” says Dr. Jeffy. In addition to being gentle, niacinamide is also beneficial when refining pores.
Willow bark: “Willow bark is actually the precursor to salicylic acid and is both an effective anti-inflammatory and anti-bacterial agent,” says Dr. Yadav. Great for unclogging pores, willow bark is excellent for use on whiteheads.
Hydrocolloid: These new kids on the block are amazingly popular because of how fast they can absorb excess fluids from a breakout. “They work to reduce inflammation, deliver treatments and also help by deterring picking,” says Dr. Jeffy.
Witch hazel: This popular astringent is often, but not exclusively, found in the natural product space. Witch hazel, a plant native to North America, is lauded for its ability to ease inflammation and soothe the skin.
How to Apply Acne Spot Treatments
When to incorporate a spot treatment is just as important as what ingredients you’re using. Potent actives like benzoyl peroxide and retinoids are best left to nighttime routines, as they can lead to sensitivity during the day. “I recommend applying spot treatments at bedtime after cleansing the face and then cleansing in the morning to remove any residue or excess product that may remain on the skin,” says Dr. Jeffy. However, items like pimple patches are amazing for both day and night use and provide an extra layer of protection to the skin while also preventing unwanted picking.
Cleanse: When using active ingredients it is always good to balance your routine with gentle products so that you don’t sensitize or cause irritation to the skin. Opt for a gentle cleanser. Or if you have a specific skin type, go for one of the best face washes for oily skin or a cleanser suited for dry skin.
Tone: Then go in with a gentle or hydrating toner (as opposed to an exfoliating toner) that will make sure all traces of dirt, bacteria and makeup are removed.
Moisturize: Choose a moisturizer for acne-prone skin that won’t further clog your pores or exacerbate existing breakouts.
Spot Treat: A little goes a long way when using a spot treatment, and is usually the last step in a skincare routine. “Spot-treatment products are too strong to be used on the entire face,” says Dr. Jeffy. So one small pump should suffice for a small area. To maintain a sanitary environment, make sure your fingers are clean if you’re applying a cream or lotion. Q-tips always come in handy to provide easy application and are typically recommended when using bottled sulfur acne spot treatments.
How Long Does It Take for Spot Treatments to Work?
The timeline to zap pimples matters less than using the right formula for the right type of blemish. “The frustrating truth is that most acne treatments can take up to six weeks to work and fully clear a blemish, but many of the below treatments can help quell a blemish and make it less painful or noticeable, making them easier to manage and conceal with makeup, if desired,” says Dr. Yadav.
It’s easy to view acne spot treatments as a quick fix — but that doesn’t mean you should go rogue and apply as frequently as you’d like. Follow the instructions on the packaging or you may inadvertently inflict unnecessary irritation. “It’s not recommended to apply most benzoyl peroxide, salicylic acid, or retinoid/adapalene formulas more than twice a day at most, as these ingredients can be quite irritating to the skin,” advises Dr. Yadav. “Depending on the type of blemish, willow bark, clay, or pimple patches may be your best bet for a constant treatment, which can be helpful ahead of a major event,” she notes.
Struggling with more cystic acne? It’s best to consult with a dermatologist for a long-term solution, which could include prescription medication or laser treatments.
How We Chose the Best Acne Spot Treatments
Since 1910, WWD — often referred to as “the fashion bible” — has been the leading industry voice of authority for senior executives in the global women’s and men’s fashion, retail and beauty communities, while also informing the consumer media that cover the market. Today, WWD’s breaking news and trend coverage continues to be a trustworthy resource for both fashion insiders and consumers alike. Our shopping editors continue to uphold WWD’s editorial standards and values with quality, expert-backed product selections.
Narrowing down the 15 best acne spot treatments was a collective effort. We conducted expert interviews with professionals in the fields of dermatology as well as aestheticians to determine top ingredients and products. We also garnered personal recommendations from them. In addition, we looked through customer reviews and product ratings while tapping into our own market research and product testing. For the March 2024 update of this article, our editors reviewed the product inclusions to eliminate any that could be at risk of containing benzene, per the Valisure report. Learn more about us here.
Meet the Experts
Dr. Paul Jarrod Frank is a board-certified dermatologist, skincare consultant, and founder of the bespoke aesthetic healthcare brand PFRANKMD. In over 20 years of private practice, he has become a world-renowned expert in minimally invasive cosmetic surgery.
Dr. Brooke Jeffy is a board-certified dermatologist, acne specialist, and founder of BTWN, a simple skincare line for teens.
Dr. Geeta Yadav is a board-certified dermatologist based in Toronto. She’s an expert in both medical and cosmetic dermatology at her practice Facet Dermatology. She holds a master’s degree in international health from Johns Hopkins and completed her dermatology training at the University of Toronto, where she still teaches today.
Meet the Authors
Jamie Wilson is a New York-based beauty writer and editor. Prior to going freelance and contributing to brands like Glamour, she previously held the title of beauty editor at Harper’s BAZAAR writing both print and digital features, trend stories, celebrity interviews, and cover stories. She can usually be found testing out new products from her Brooklyn apartment, including top acne spot treatments.
Claire Sullivan is the Senior Beauty and Lifestyle Commerce Editor for Footwear News and WWD, where she writes and edits beauty, fashion and lifestyle stories. She has over six years of experience as a writer and editor for national media outlets including Martha Stewart Living, Martha Stewart Weddings, InStyle, and Byrdie. She keeps her finger on the pulse of all things related to beauty and wellness, as well as the latest shopping trends and clothing brands. Sullivan contributed to the March 2024 update of this article, refreshing product selections after a round of testing and updating the article throughout after an interview with a dermatologist regarding the Valisure report regarding benzene in OTC acne treatments.
This article was fact checked and reviewed by Leanna Yip, a veteran copy editor with over 12 years of experience, including eight years text editing researched shopping stories and in-depth product guides across several categories, including fashion, beauty, home, footwear, tech, gifts, and more.
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