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A health professional holds a vial of Janssen/J&J's COVID-19 vaccine in Pamplona, Spain on April 22, 2021. Abigail, a 29-year-old from New York City who asked to use a pseudonym to preserve her privacy, knew to expect some side effects after she got her second Pfizer-BioNTech COVID-19 vaccine in February. While scientists have not confirmed that COVID-19 vaccines can cause menstrual changes like Abigail’s, she feels confident the shot was her trigger, since she experienced something similar after a probable case of COVID-19 last spring.