Advertisement

CinCor Pharma Sinks After Disappointing Data From Hypertension Trial

Vandana Singh
·1 min read

  • CinCor Pharma Inc (NASDAQ: CINC) announced topline results and completion of its Phase 2 HALO trial of baxdrostat in patients with uncontrolled hypertension taking up to two blood pressure medications at the maximally tolerated doses. 

  • The study did not achieve statistical significance on its primary endpoint evaluating change from baseline in mean seated systolic blood pressure (SBP) in the intention to treat (ITT) population.

  • The data exhibited a placebo-adjusted reduction in SBP of 12.6 mmHg at the 2 mg dose. The safety profile and tolerability of baxdrostat were consistent with previously reported Phase 2 BrigHtn data in resistant hypertension.

  • The trial showed a statistically significant reduction in SBP in the prespecified non-Hispanic subgroup analysis.

  • The non-Hispanic population of HALO represented 46% (116/249) of the ITT population in the study but represented approximately 81-89% of the hypertensive population of the U.S.

  • In combination with BrigHtn, HALO informs the dose and study populations anticipated to be recruited into Phase 3 trials pending confirmation by the FDA at the planned end of Phase 2 meeting in January 2023. Phase 3 trials are expected to begin in the first half of 2023.

  • Baxdrostat’s clinical program remains on track for a potential NDA submission in 2025.

  • Price Action: CINC shares are down 47.68% at $13.88 on the last check Monday.

See more from Benzinga

ADVERTISEMENT

Don't miss real-time alerts on your stocks - join Benzinga Pro for free! Try the tool that will help you invest smarter, faster, and better.

© 2022 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.