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Monday, 5/21 at 9 PM on Fox

Hugh Laurie will make his final rounds as the gloriously grumpy Dr. Gregory House when Fox's medical drama ends its eight-season run. And he'll be joined by a host of old colleagues: Ex-cast members Olivia Wilde, Kal Penn, and Jennifer Morrison are set to return for the series finale. But with an episode title like "Everybody Dies," it sounds like the series plans to go out on a grim note. Is this a hint that we'll be saying goodbye to the cancer-ridden Dr. Wilson?

More on Upcoming Finales

12 Must-See Finales

'Tis the season for finales, and that means guest stars galore, shocking twists, explosive cliffhangers, and tons more heading to your TV. With so much going on, you'll want to make extra certain you don't miss any of your favorite shows' big finales. Don't worry, we've got your back. Click through this slideshow for our guide to the 12 must-see finales this season.