Hollywood is ready to Stand Up to Cancer for the organization's third prime-time television fundraising special.
Gwyneth Paltrow and Joel Callen of Tenth Planet Productions will produce the broadcast as they try to rally support in the fight against cancer.
The star-studded event will include appearances by Julia Roberts, Matt Damon, Jessica Biel, Samuel L. Jackson, Seth Rogen, Emma Stone, Simon Baker, Chelsea Handler, Joe Manganiello and others.
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Taylor Swift, Coldplay, Alicia Keys and Tim McGraw will perform.
The first two Stand Up to Cancer telecasts aired Sept. 5, 2008, and Sept. 10, 2010. The organization has already earned $180 million in donations toward their innovative cancer research.
The commercial-free fundraiser will air live Friday, Sept. 7 at 8/7c simultaneously on ABC, CBS, Fox, NBC, E!, HBO, Showtime, TBS and VH1.