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Saquon Barkley, Kenny Golladay, Kadarius Toney all out for banged-up Giants vs. Panthers

NEW YORK — Saquon Barkley, Kenny Golladay and Kadarius Toney officially will sit out Sunday’s game against the Carolina Panthers. That’s on top of left tackle Andrew Thomas going on injured reserve earlier in the week.

A slew of other offensive weapons are questionable, too: tight end Evan Engram (calf) and wide receivers John Ross (hamstring), Sterling Shepard (hamstring) and Darius Slayton (hamstring).

Barkley (sprained left ankle) and Golladay (hyperextended right knee) are missing a second straight game. Toney (right ankle) lasted six snaps in last week’s loss against the Rams. Thomas (left foot, right ankle) is done until after the Week 11 bye at least.

Defensive tackle Danny Shelton (pec) is doubtful for Sunday on top of all that.

This could mean call-ups or a roster signing for up to three practice squad players: wideout David Sills, DT David Moa and TE Chris Myarick.

The Giants were one of the healthiest teams in the NFL last season. Now they are inundated by injuries, including the soft-tissue injuries they did such a great job managing in 2020.

“We’re always looking at that and seeing what we’re doing,” Joe Judge said. “There’s a number of things that factor into that making sure we account for everything that goes into it. Some injuries you just can’t avoid. Some other ones you gotta look internally at what you’re doing in terms of players throughout the course of the season and how you’ve got to handle things differently.”

Barkley, Golladay and Toney did not practice all week. Engram was upgraded to limited participation on Friday after sitting out Thursday with a calf injury. He’d missed the Giants’ first two games with a calf, as well.

Shepard missed two games with a hamstring injury before returning against the Rams, then popped up on the injury report again Thursday.

Tight end Kaden Smith (knee), corner Sam Beal (hamstring), and left guard Ben Bredeson (left hand) were limited on Friday along with Engram, Ross, Shelton, Shepard and Slayton.

The Panthers, in addition to Christian McCaffrey (hamstring) being on injured reserve, will be without edge Shaq Thompson (foot), WR Terrace Marshall Jr. (concussion) and FB Giovanni Ricci (concussion). And left tackle Cam Erving (illness) is questionable.

Wilson back

Practice squad offensive lineman Isaiah Wilson returned to practice Friday after being kept out of the building on Wednesday and Thursday with what Judge called a stomach “bug.” Wilson, a former failed Titans first-round pick with a laundry list of off-field issues, has not been made available to the local media despite repeated requests since signing on Sept. 30.