The Red Devils have all but wrapped up second place in the Premier League, so the focus now turns towards European football.
Now they resume the tie at Old Trafford in the hope the job will be completed without any major hiccups.
If they can do the business and come through Granada this evening, Ajax or Roma await in the semi-finals.
Here’s all you need to know ahead of the fixture.
When is it?
The match will kick off at 8pm GMT on Thursday, April 15.
How can I watch it?
The fixture will air live on BT Sport 2. Subscribers can also stream the action live on the broadcaster’s website and app.
Man Utd: De Gea; Wan-Bissaka, Tuanzebe, Lindelof, Sandro; Fred, Matic; Greenwood, Fernandes, Pogba; Cavani
Granada: Silva, Foulquier, Vallejo, German, Neva; Gonalons, Montoro; Machis, Herrera, Kenedy; Soldado
Man Utd: 4/9
Manchester United will be expected to coast through this one as they set their sights on the semi-finals. Providing they can avoid conceding an early goal, this should be a comfortable night’s work for the Red Devils. 2-0 Man Utd (agg 4-0).