LIVE: Colts fall to Titans 24-17 in Week 4 action

The Indianapolis Colts are trying to earn their first AFC South victory of the season in NFL Week 4 action against the Tennessee Titans.

The Colts (1-1-1) are coming off an upset victory over the Kansas City Chiefs, while the Titans (1-2) earned their first win of the season last week by holding off a late rally by the Las Vegas Raiders.

Joel A. Erickson, Nate Atkins, Akeem Glaspie and Gregg Doyel will have updates throughout. We'll have highlights and milestones here, so please remember to refresh.

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Final: Titans 24, Colts 17

The Colts are 1-2-1 overall and 0-2-1 in AFC South play. The Titans are 2-2.

Matt Ryan went 27-of-37 for 356 yards, with 2 touchdowns to Mo Alie-Cox and an interception. He also fumbled three times, losing one. Colts tight ends had 11 catches for 180 yards.

Jonathan Taylor had 20 carries for 42 yards, most of those yards coming in the third quarter. Zaire Franklin was in on 15 tackles.

The Colts were -3 in turnover margin, one squelching a promising second-half drive and another leading to Tennessee's first score.

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Ryan Tannehill went 17-of-21 for 137 yards and 2 touchdowns, and the Colts sacked him 3 times. Derrick Henry had 22 carries for 114 yards and a touchdown (99 yards in the first half). Former Colts defensive lineman Denico Autry sacked Ryan twice, one forcing an early fumble.

The Colts lost linebacker Shaquille Leonard to a concussion in the first half.

The Colts visit Denver to play the Broncos on Thursday night.

1:58 left 4Q: Colts miss a field goal

Chase McLaughlin is wide left on a 51-yard field goal. Colts have three timeouts left.

Denico Autry sacks Matt Ryan on third down, putting the Colts at the Tennessee 34.

Matt Ryan hits Ryan Pierce for 44 yards, driving to the Titans 22.

4:46 left 4Q: Colts force another Titans punt

Kwity Paye gets the sack of Ryan Tannehill one play after Dayo Odeyingbo stuffs Derrick Henry. The Titans have been outscored 64-7 in the second half this season. The Colts have another chance to tie, starting at their 34.

8:40 left 4Q: Titans recover a Jonathan Taylor fumble

Taylor was fighting for a first down, but the Titans strip the ball and get it at their 22.

Matt Ryan eclipses 300 yards for the game, the 75th such game in his NFL career. Ryan hits Mo Alie-Cox for 34 yards to start the drive.

Titans WR Treylon Burks leaves the game with an ankle injury.

14:53 left 4Q: Colts punt, poorly

Matt Haack's punt goes out of bounds at the Tennessee 20. That's a 19-yard punt.

Entering fourth quarter

The Colts were driving before the Titans get to Matt Ryan again and force a fumble on a sack. The Colts recover. They are deciding whether to try a 57-yard field goal. Kylen Granson has 4 catches for 62 yards.

5:36 left 3Q: Colts stop the Titans again

After a 3-and-out series, the Colts take over at their 20.

7:26 left 3Q: Matt Ryan to Mo Alie-Cox, part 2

The connection from 7 yards completes an 8-play, 67-yard drive. Jonathan Taylor, who had 19 rushing yards at half, is up to 40. Titans 24, Colts 17

12:35 left 3Q: Colts force first Titans punt

Dayo Odeyingbo sacked Ryan Tannehill and the Colts force a Tennessee punt. They take over at their 33.

Halftime: Titans 24, Colts 10

The Colts defense has done little to stop the Titans.

Ryan Tannehill is 12-of-15 for 103 yards and 2 touchdowns, and Derrick Henry has rushed for 99 yards and a score.

The Colts came in allowing an NFL-best 2.6 yards per carry, but Henry is well beyond that.

Colts quarterback Matt Ryan has been intercepted and has lost a fumble, issues that have plagued him this season. He is 12-of-20 for 170 yards, with a touchdown to Mo Alie-Cox. Jonathan Taylor has 11 carries for 19 yards.

Colts linebacker Shaquille Leonard, who made his season debut, got knocked out of the game when teammate Zaire Franklin leveled him when trying to make a tackle. The Titans scored on that play.

The Titans ran out of time in Colts territory and could not attempt a last-second field goal before halftime arrived.

2:13 left 2Q: Colts drive for a touchdown

Matt Ryan hits Mo Alie-Cox from 14 yards. Colts drive 75 yards on 9 plays. Titans 24, Colts 10

7:40 left 2Q: Titans are blowing out the Colts

Ryan Tannehill hits rookie Chigoziem Okonkwo 8 yards. Colts linebacker Shaquille Leonard, who got leveled by teammate Zaire Franklin, left the game after this play.

Titans have 92 rushing yards and 71 passing yards. Titans 24, Colts 3

9:34 left 2Q: Matt Ryan's pass is intercepted

Teair Tart deflects and catches the pass at the Colts 28.

9:39 left 2Q: Titans add a field goal

Randy Bullock hits from 44 yards. 3 possessions, 3 scores for Tennessee. Titans 17, Colts 3

13:25 left 2Q: Colts get on the board

Chase McLaughlin kicks a 27-yard field goal. Titans 14, Colts 3

Michael Pittman Jr. catches two passes, one at each side of the end zone, but he's out of bounds on both.

Entering second quarter: Colts are driving

Indianapolis has 2nd-and-8 at the Tennessee 24-yard line. Matt Ryan has hit Kylen Granson, Michael Pittman Jr. and Parris Campbell for first downs. Ryan is 5-of-10 for 65 yards. Jonathan Taylor has 8 carries for 13 yards.

3:46 left 1Q: Derrick Henry scores with ease

The Titans running back goes 19 yards around right end. The Titans easily drive 75 yards. Henry has 40 rushing yards and Ryan Tannehill is 5-of-5 passing for 58 yards. Titans 14, Colts 0

8:00 left 1Q: Titans score with a short field

Ryan Tannehill hits Robert Woods from 7 yards. Tennessee has scored a touchdown on its opening drive in every game this season. Tannehill scrambled to convert a third-down play earlier in the drive. Titans 7, Colts 0

10:47 left 1Q: Matt Ryan loses another fumble

Former Colt Denico Autry jars the ball loose, and the Titans recover at the Colts 31. Colts quarterback Matt Ryan has fumbled an NFL-leading 8 times this season and has been sacked 13 times. This is his third lost fumble.

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11:30 a.m.: Shaquille Leonard is active

Colts inactives: S Julian Blackmon, QB Sam Ehlinger, CB Dallas Flowers, C Wesley French, WR Dezmon Patmon.

LB Shaquille Leonard, who missed the first three games of the season, is active. So is DT DeForest Buckner, who was on the injury report all week.

Titans inactives: OL Le'Raven Clark, LB Wyatt Ray, LB Ola Adeniyi, DB Ugo Amadi, LB Zach Cunningham, DB Amani Hooker, DB Theo Jackson.

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This article originally appeared on Indianapolis Star: Colts vs Titans: NFL Week 4 live scores, highlights, updates