The duo missed the Gunners’ drab draw with Crystal Palace on Thursday, where Mikel Arteta’s side once again struggled to break down their opponent. Newcastle have been in worse form of late, and they followed up their FA Cup defeat with a loss to bottom of the table Sheffield United.
FOLLOW LIVE: Arsenal vs Newcastle – Latest updates
The Magpies took the Gunners to extra time in the third round before goals from Emile Smith Rowe and Pierre-Emerick Aubameyang secured the win.
Ahead of Monday's visit of the Magpies, Arteta says he feels the injuries suffered by the likes of Tierney and Pablo Mari will become more commonplace before the end of the season.
Asked if there was a risk of burnout due to the amount of games, Arteta replied: "Yes. We have been trying to manage it.
"But the reality is that the fixtures are what they are and we didn't have a pre-season, which is why - and we've talked about it many, many times - one of the reasons we wanted the five subs.
"It was exactly that. But this is just the consequences and this will happen more and more, I think, and to more clubs."
Here’s everything you need to know about the match.
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When is it?
The fixture will kick-off at 8pm GMT at the Emirates Stadium.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event, with coverage starting from 7pm GMT. Subscribers can also stream the match via the Sky Go app.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
What is the team news?
Arsenal will be without Pablo Mari, who missed the draw with Palace due to a calf injury. Gabriel Martinelli and Kieran Tierney will be assessed ahead of the clash.
Steve Bruce is hopeful that both Jamal Lewis and Jonjo Shelvey could return from knee and groin issues respectively, but Ryan Fraser is suspended following his sending off at Sheffield United. Jamaal Lascelles will be assessed as he continues his recovery from Covid-19.
AFC XI: Leno, Cedric, Luiz, Holding, Tierney, Partey, Xhaka, Saka, Smith Rowe, Aubameyang, Lacazette
NUFC XI: Darlow, Krafth, Lascelles, Clark, Lewis, Shelvey, M. Longstaff, Almiron, Joelinton, Carroll, Wilson
Both sides are in worrying form, and their FA Cup clash didn’t exactly set pulses racing. However, Newcastle are in a really bad run under Bruce, and it wouldn’t be a surprise if Arsenal nicked a truly scrappy game. 1-0 Arsenal.