Detroit 's addition of Ian Kinsler only figures to add to his woes.
Danks lost all three 2013 outings to the Tigers and has dropped his last five in Detroit heading into Monday night's opener of a four-game set.
These AL Central rivals will start their 19-game season series with a matchup that figures to favor the home team.
Danks (1-0, 3.32 ERA) went 0-3 with a 5.48 ERA in three starts against the Tigers (9-6) last year to drop to 4-10 lifetime against them. The left-hander is 0-5 with a 6.28 ERA in his last five outings at Comerica Park, with the five defeats tying his highest total at any visiting ballpark.
The Detroit hitter that had given him the most trouble over the years is Austin Jackson, a .378 hitter against Danks. Kinsler, acquired from Texas in the offseason in the Prince Fielder deal, is even better at .387.
Danks gave up one run in six innings Wednesday in a 6-4, 14-inning loss to Boston.
Kinsler was part of one of the strangest plays in recent memory in Sunday's 2-1 home win over the Los Angeles Angels. He scored in the first inning when the Angels made three errors on one play and Jackson scored another unearned run in the sixth.
Miguel Cabrera went 0 for 3 to finish the series 1 for 11 with four strikeouts, and the reigning two-time AL MVP is 8 for 47 (.170) in his last 12 games. He's 10 for 35 against Danks, but 0 for 9 against lefties this year.
The Tigers will start Anibal Sanchez (0-1, 3.21), who is 2-2 with a 3.04 ERA against the White Sox in four starts - all last year.
The right-hander has yet to last past the fifth inning, pitching that many innings and giving up three runs in a 3-2 loss to Cleveland on Wednesday.
Sanchez will get his first look at Cuban rookie Jose Abreu, who is 5 for 9 in his last two games after a 1-for-25 slump.
Abreu and Jordan Danks each had two-run homers as Chicago (9-10) ended a four-game slide with its highest scoring effort of the season, a 16-2 win at Texas on Sunday.
Marcus Semien turned in his second four-hit effort and finished with a career-best four runs. He tripled in three runs after an intentional walk in the sixth inning.
''That's a little fire, it gives you a little fire when you see that happen right in front of you,'' he said. ''I'm glad I got the result and we as a team got the result.''
Tyler Flowers and Dayan Viciedo each added three hits and scored three runs for Chicago, which has scored the most runs in the majors with 106 but owns baseball's second-worst at 5.18 ERA.
Cabrera, Torii Hunter and Victor Martinez combined for 11 homers and 30 RBIs as Detroit won 12 of 19 from Chicago last year.
The White Sox have dropped 24 of their last 30 games at Detroit.