CHICAGO (AP) — Even Phil Humber couldn't solve the White Sox's troubles with the Minnesota Twins.
Humber (8-5) lasted 3 2-3 innings, allowing season-highs of 11 hits and six runs, and the Twins beat the White Sox 6-2 on Thursday night.
Chicago has lost 27 of 33 overall against its AL Central rivals, who beat the White Sox for the eighth straight time.
"We just can't get it done," White Sox manager Ozzie Guillen said. "The reason is I don't know the reason."
One of baseball's biggest surprises this season, Humber had gone 6-1 with a 2.52 ERA over his last 10 starts, leading to cries that he should have made the AL All-Star team. He didn't show that form Thursday, as the Twins jumped on him with an aggressive small-ball attack from the outset.
"It was not a whole lot of fun out there," Humber said. "Even when I did execute my pitches it seemed like they were putting the barrel on the ball."
Joe Mauer had three hits, drove in two runs and was flawless in his first game at first base for Minnesota.
"Coming in here, Chicago, I always feel pretty good at the plate," Mauer said. "It's just one of those things, the park is a great hitting park. I was just more relaxed, which is good."
In the bottom of the first, Mauer was immediately tested at his new position where he hadn't played since 2002 in a Class A game. He nabbed Omar Vizquel's hard liner to start an unassisted double play. Then he scooped a grounder hit by Adam Dunn and stepped on first, accounting for all three outs in the inning.
"I think that first ball (Vizquel's liner) when we hit it that was like a punch in the stomach," Guillen said. "There we go first and third, second and third. He made the play. First base is not an easy place to play. Lot of people think it's very easy."
Ben Revere also had three hits and two RBIs for the Twins. Tsuyoshi Nishioka had two hits and scored two runs for the Twins, who had 13 hits, including 12 singles.
"We were running around the bases pretty good, slapping the ball around," Twins manager Ron Gardenhire said. "Executed, got on second, got them over and got them in. A lot of things went our way early in the ballgame tonight against a very good pitcher."
Carl Pavano (6-6) allowed six hits and two runs over seven innings for Minnesota. He walked two and struck out four.
"He just seems to throw the ball well against us," Chicago left fielder Juan Pierre said. "He throws a lot of strikes. Mixes it up. Doesn't get in a pattern where you can follow what he's going to do."
Mark Teahen hit his third homer for Chicago, a two-run shot in the fifth.
Minnesota has beaten Chicago all five times in their meetings this season and have won 13 of its last 15 games at U.S. Cellular Field. The White Sox have dropped four of five overall.
"They're a good ballclub," Mauer said. "They're one of the teams we're looking up at. We always have good games when we play those guys."
Mauer caught Humber a couple of years ago in Minnesota, but the righty isn't the same pitcher he was then.
"(Humber has) been throwing the ball great," Mauer said. "I caught him a couple of years ago and he's really put it together. We were just trying to get pitches we could handle."
White Sox lefty Hector Santiago retired the first eight batters he faced and threw 4 1-3 scoreless innings.
"(Santiago) has got a chance to be a good one," Guillen said. "This kid's got some heart."
If the White Sox are going to climb out of their below-.500 stupor, they're going to have to figure out how to beat their division foes.
"They can be beat," Pierre said. "They're not undefeated. They might be undefeated against us."
NOTES: Before the game, it was announced that Chicago 1B Paul Konerko had won MLB's "final vote" and earned the last spot on the AL All-Star roster. Konerko received a loud ovation when he came to bat in the first inning. This will be his fifth All-Star appearance. ... Twins trainer Rick McWane said that an MRI on starter Scott Baker showed a mild flexor strain. As a precaution, Baker will skip his scheduled start on Sunday and will be re-evaluated after the All-Star break. He is undergoing treatment for the injury and isn't being allowed to throw. ... Santiago had the longest scoreless relief outing for the White Sox since Tony Pena threw six shutout innings against Oakland on Sept. 20. ... Dunn went 0 for 4, striking out three times, the last against lefty reliever Glen Perkins. Dunn's average dropped to .163. He's struck out an AL-high 113 times this season and is 2 for 58 (.034) against lefties this season.