- Philipp Kholschreiber beat John Isner 7-6 (7/4), 4-6, 7-6 (7/2), 7-6 (7/4) on Saturday to end US interest in the men's draw at the US Open.
It's the third straight year that Kohlschreiber has eliminated Isner at the same stage at Flushing Meadows.
Isner and Sam Querrey were the only US men to make it to the third round, and top-seeded Novak Djokovic easily neutralised Querrey's big serve earlier Saturday to dispatch the 57th-ranked American 6-3, 6-2, 6-2.
Andy Roddick's 2003 US Open triumph marks the last time an American man hoisted a Grand Slam trophy.
The men's woes leave five-time women's champion Serena Williams -- gunning for a third straight title -- as the only American still standing in singles.