Speaking for the first time about James' surprise move, which was announced last Friday, Spoelstra said he wishes James all the best in Cleveland.
"He seemed at peace with the decision," Spoelstra told the South Florida Sun-Sentinel newspaper. "We don't have any regrets. He shouldn't have any regrets. It was a historic four-year run."
The Heat reached the finals four straight years and won two championships during James' south Florida stint.
James' exit left Miami scrambling to piece together a competitive roster after losing to the San Antonio Spurs in last year's NBA finals.
The US media reported Wednesday that Wade re-signed for two years and $31 million while Bosh signed earlier for five years and $118 million.