Photo by: Astrazeneca
2010 US Sales: $3.8 billion Company: AstraZeneca Crestor is a cholesterol drug designed to help lower LDL (bad) cholesterol and raise HDL (good) cholesterol. It also slows the progressions of atherosclerosis, a condition that blocks arteries. Crestor is one of the most profitable drugs in AstraZenecaâ€™s portfolio. The patent for Crestor expires in 2016, at which time generic competition will be fierce.