Cor Pulmonale Symptoms and Treatment
This right-sided heart failure is associated with COPD
Medically reviewed by Daniel More, MD
Cor pulmonale occurs when the blood pressure in the pulmonary artery—which carries blood from the heart to the lungs—increases and leads to the enlargement and subsequent failure of the right side of the heart. It also can occur with chronic low oxygen levels due to conditions like chronic obstructive pulmonary disease (COPD).
Cor pulmonale symptoms can include fatigue, swelling, and chest pain. Cor pulmonale is a progressive condition that can rapidly worsen. If left untreated, it may be life-threatening.
This article explains cor pulmonale causes and how the condition is diagnosed. While there is no cure and cor pulmonale won't go away, a number of treatment options can help to improve symptoms.
Cor Pulmonale Symptoms
The early symptoms of cor pulmonale can go unnoticed because the causative lung disease also causes symptoms, and some effects may be similar. To make matters even more confusing, symptoms of cor pulmonale often develop as the underlying lung condition worsens.
Common effects of cor pulmonale include:
Wheezing and coughing
Intolerance of exercise or even mildly strenuous physical activity (like walking upstairs)
General fatigue
Shortness of breath (dyspnea)
Dizziness
Edema (swelling of the feet and/or ankles)
When Cor Pulmonale Is an Emergency
With cor pulmonale, some potentially life-threatening symptoms may signal a medical emergency include. Seek immediate help if you experience:
Severe dyspnea at rest
Enlarged neck veins (jugular vein distention)
Syncope (loss of consciousness, fainting)
Abdominal swelling
Bluish tinge to your skin, nail bed, lips, or gums (cyanosis)
Pulmonary hypertension and cor pulmonale can lead to severe fluid retention which, in turn, can cause life-threatening dyspnea, shock, and even death.
Related: How to Manage Progressive Pulmonary Hypertension
Cor Pulmonale Causes
This type of right-sided heart disease can develop slowly or suddenly, and it is always caused by lung disease. COPD is the most common cause of cor pulmonale, but there are others as well. Often, cor pulmonale is more severe if you also have other types of heart disease, such as an arrhythmia or a history of a heart attack.
Common causes of cor pulmonale include:
Scleroderma of the lungs
Pulmonary embolism (PE), or blood clot in the lungs
Lung tissue damage
Acute respiratory distress syndrome (ARDS)
Is Cor Pulmonale Related to COPD?
COPD is a common cause of heart failure, especially cor pulmonale. COPD is a group of pulmonary diseases that include emphysema and chronic bronchitis, which are progressive conditions that are associated with a number of complications.
Related: Health Conditions Associated With COPD
Effect on the Heart
The heart has four chambers—left atria, left ventricle, right atria, and right ventricle. Cor pulmonale is right heart failure due to high pressure in the pulmonary arteries (arteries that lead from the heart to the lungs). As this condition develops, the right ventricle becomes dilated (widened) and thickened, and later the right atrium may be affected as well.
Explainer
Pulmonary hypertension occurs when the pressure in the arteries of the lungs are higher than they should be, which eventually makes it harder for the right ventricle to do its job. Any condition that leads to pulmonary hypertension can put a strain on the right ventricle.
Related: Why COPD Causes Swelling
How Is Cor Pulmonale Diagnosed?
The diagnosis for cor pulmonale is usually made in the healthcare provider’s office. A physical exam typically picks up any abnormal heart sounds or rhythm, fluid retention, or protruding neck veins.
To provide a definitive diagnosis, your healthcare provider may also perform the following tests:
Echocardiogram, which uses sound waves to visualize the heart
Computed tomography (CT) scan of the chest
Arterial blood gases (ABG) blood test
Pulmonary artery catheterization, with the insertion of a catheter into the pulmonary artery to check for heart failure, also can be done. A scan to check for ventilation/perfusion (VQ) mismatch, which uses radioactive materials to examine the airflow and blood flow into the lung, also can be done.
Related: What Is Ventilation/Perfusion (V/Q) Mismatch?
Cor Pulmonale Treatment
Treatment for cor pulmonale is focused on addressing the underlying illness. There are also a few treatments that can alleviate some effects of heart failure.
Management of the underlying lung condition can include:
Steriods
Antibiotics if you have a lung infection
Blood thinner or interventional procedure for the management of a PE
Related: Pulmonary Embolism Treatment and Management
The use of calcium channel blockers is complicated when it comes to cor pulmonale. These drugs prevent calcium from entering the cells of blood vessel walls and may relax the pulmonary arteries, reducing pulmonary hypertension, but they may also adversely affect the heart and respiratory function in some instances.
Treatments aimed at alleviating the effects of cor pulmonale include:
Anticoagulants (blood thinners), which may decrease mortality in persons with pulmonary hypertension
Beta-blockers to improve heart function
Diuretics, such as spironolactone, or renin-angiotensin system inhibitors to reduce edema
Cholesterol-lowering agents to reduce the risk of blood clots
A heart transplant may be considered in very advanced cases, and a lung transplant may be considered for some types of lung disease. Keep in mind that pulmonary hypertension associated with cor pulmonale has negative impact on life expectancy.
Related: Everything You Need to Know About Getting a Heart Transplant
Summary
Cor pulmonale is a serious heart condition that develops as a complication of advanced lung disease, most often COPD. Symptoms include increasing shortness of breath with exertion, chest pain, dizziness, and a bluish tinge to the skin (cyanosis).
Treatment can include supplemental oxygen, and a number of medications to protect against blood clots and improve heart function and blood flow.
Because there is no treatment that can reverse cor pulmonale, prevention is key. Strategies for prevention include avoidance of smoking and airborne pollution as well as careful management of your lung disease. Talk with your healthcare provider if you have concerns about cor pulmonale.
Read the original article on Verywell Health.