New York (AFP) - Philipp Kholschreiber beat John Isner 7-6 (7/4), 4-6, 7-6 (7/2), 7-6 (7/4) on Saturday to end US interest in the men's draw at the US Open.
It's the third straight year that Kohlschreiber has eliminated Isner at the same stage at Flushing Meadows.
Isner and Sam Querrey were the only US men to make it to the third round, and top-seeded Novak Djokovic easily neutralized Querrey's big serve earlier Saturday to dispatch the 57th-ranked American 6-3, 6-2, 6-2.
That left the 13th-seeded Isner to battle Kohlschreiber for a chance to tackle Djokovic in the fourth round, and even a stunning 44 aces and 77 winners weren't enough to overpower the German.
Only three American men, from 12 home-grown contenders, had made it to the second round, the fewest in US Open history.
Tim Smyczek was beaten in the round of 64 by Spain's Roberto Bautista Agut.
Andy Roddick's 2003 US Open triumph marks the last time an American man hoisted a Grand Slam trophy.
The men's woes leave five-time women's champion Serena Williams -- gunning for a third straight title -- as the only American still fighting.