The hot category of initial public offerings in the biotechnology sector continues, with two set to trade Friday: Seer and Silverback Therapeutics. Both priced above their estimated range.
- Yahoo News
Former President Donald Trump’s “big lie” about a stolen election may have been discredited over and over in the courts, and disgraced by the attack on the U.S. Capitol, but the corrosive effect of his dishonesty will linger on, complicating efforts to strengthen American elections.
- Yahoo News
Black National Guardsman describes being deployed to protect Biden’s inauguration: 'I just felt this huge sense of pride'
As most of the 25,000 National Guardsmen who were called upon to protect Washington, D.C., during the presidential inauguration began heading home this week, one Black service member agreed to speak to Yahoo News about the experience of protecting the nation’s capital in the wake of a pro-Trump riot on Capitol Hill.
- NBC News
President Joe Biden vowed to ultimately put an end to private prisons, but activists says the move isn't enough to fully address mass incarcerations.
- The Telegraph
The leader of the Proud Boys extremist group has been unmasked as a "prolific" former FBI informant. Enrique Tarrio, 36, worked undercover exposing a human trafficking ring, and helped with drug and gambling cases, according to court documents. Tarrio's documented involvement with law enforcement related to the period 2012 -2014. There was no evidence of him cooperating after that. But the revelation raised further questions over why police did not take further steps to secure the US Capitol ahead of the riots on Jan 6. At least half a dozen members of the Proud Boys were arrested over involvement in the riots. Tarrio denied ever being an informer, telling Reuters: "I don’t know any of this. I don’t recall any of this."
Treating China as a "strategic rival" of the United States is a misjudgement that could lead to mistakes, China's ambassador to the United States said in a speech to an online forum. Since the Trump administration defined China as a strategic rival in 2018, Washington and Beijing have frequently clashed over issues ranging from trade to Beijing's handling of the coronavirus, and the new administration of President Joe Biden is expected to maintain pressure on China. In the first major speech by a Chinese official on relations between the world's two biggest economies since Biden took office, Ambassador Cui Tiankai reasserted China's long-standing position of seeking peaceful coexistence with the United States, while warning it not to cross China's red lines.
- Associated Press
Iranian President Hassan Rouhani on Wednesday criticized Iran's hard-liner dominated judiciary over last week's prosecution of the countrys telecommunications minister. Mohammad Javad Azari Jahromi was released on bail after he was summoned for prosecution. Judiciary officials cited his refusal to block Instagram and impose limitations on the bandwidth of other foreign social media and messaging systems.
- The Independent
Biden’s new sign language interpreter runs a right-wing Facebook group and has been pictured in a MAGA hat
One video featuring Heather Mewshaw is titled ‘Joe Biden is literally and legally not the President elect’
- Architectural Digest
Let’s get loudOriginally Appeared on Architectural Digest
- The Telegraph
Russian authorities target Navalny's associates and wife in series of police raids ahead of protests
Russian authorities raided the homes of jailed Kremlin critic Alexei Navalny and his associates on Wednesday, piling pressure on opposition figures ahead of a major rally planned for this weekend. Masked police on Wednesday afternoon broke down the door of Mr Navalny’s rented flat despite the pleas from his wife who was inside, asking for her lawyer, Veronika Polyakova. Ms Polyakova arrived at her house but was not allowed in to witness the search, a clear violation of the Russian law,she told the Dozhd TV channel. In the biggest wave of police action against the opposition in months, law enforcement agents raided at least seven homes on Wednesday, including a Moscow property owned by Mr Navalny but where he has not lived for years, and the office of his associates who run his YouTube channel. A video posted online by Lyubov Sobol, a close ally of Mr Navalny, showed black-clad masked men break down the door and walk into the office.
- The Conversation
Why it takes 2 shots to make mRNA vaccines do their antibody-creating best – and what the data shows on delaying the booster dose
After a second dose of the COVID-19 mRNA vaccine, a swarm of antibodies attacks the virus. Kateryna Kon/Science Photo Library via Getty ImagesWith the U.S. facing vaccination delays because of worker shortages and distribution problems, federal health officials now say it’s OK to push back the second dose of the two-part vaccine by as much as six weeks. As an infectious disease doctor, I’ve been fielding a lot of questions from my patients as well as my friends and family about whether the COVID-19 vaccine will still work if people are late receiving their second dose. Why you need two doses 3-4 weeks apart Two doses, separated by three to four weeks, is the tried-and-true approach to generate an effective immune response through vaccination, not just for COVID but for hepatitis A and B and other diseases as well. The first dose primes the immune system and introduces the body to the germ of interest. This allows the immune system to prepare its defense. The second dose, or booster, provides the opportunity for the immune system to ramp up the quality and quantity of the antibodies used to fight the virus. In the case of the Pfizer and Moderna COVID-19 vaccines, the second dose increases the protection afforded by the vaccine from 60% to approximately 95%. Why the CDC decided receiving the second dose within 42 days is OK In the clinical trial, the second dose of the Pfizer vaccine was administered as early as day 19 and as late as day 42 to 93% of the subjects. Since protection was approximately 95% for everyone who was vaccinated within this time “window,” there is little reason not to allow some flexibility in the timing of the second dose 2. As more vaccine becomes available, the timing of the second dose should be close to four weeks for the Pfizer and Moderna vaccines. But the good news is that even while supplies remain limited, the science suggests that there’s nothing bad about getting a second dose as late as 42 days after the first. What the immune system does between the first and second dose The biology through which the mRNA vaccines induce their protection from COVID-19 is fundamentally different from that with other vaccines. Pfizer and Moderna vaccines use messenger RNA that encodes the spike glycoprotein. Upon injection of the vaccine, the mRNA enters into immune cells called dendritic cells. The dendritic cells use the instructions written in the mRNA to synthesize the hallmark spike glycoprotein, which characterizes the SARS-CoV-2 virus that causes COVID-19. These immune cells then show the spike glycoprotein to B-cells, which then make anti-spike antibodies. Dendritic cells recognize viruses and present information about the spike protein to T-cells. T-cells provide information about the viral spike protein to B-cells, which are transformed to memory B-cells that store information about the virus. When this memory B-cell is activated with an infection or the second dose of the vaccine, this causes some of the B-cells to change into plasma B-cells that secrete protective antibodies that fight the virus. Kateryna Kon/Science Photo Library via Getty Images The mRNA vaccines are uniquely capable of inducing a special kind of immune cell – called a T-follicular helper cell – to help B-cells produce antibodies. The T-cells do this through direct contact with the B-cells and by sending chemical signals that tell the B-cells to produce antibodies. It is this help in antibody production that makes these vaccines so effective. But not all B-cells are the same. There are two kinds that make anti-spike antibodies: long-lived plasma cells and memory B-cells. The long-lived plasma cells, as their name implies, live in the bone marrow for years after vaccination, continuously churning out antibody – in this case anti-spike antibody. These long-lived B-cells do not need to be boosted. The memory B-cells, on the other hand, live in a state akin to hibernation. They do not produce antibodies until stimulated by a booster of the vaccine, or are exposed to infection with the coronavirus that causes COVID-19. That is the reason we need that second dose. Together these two types of B-cells provide a constant level of protection. What happens if you don’t get the Pfizer or Moderna second dose on time? With current vaccine shortages, and problems with setting up the infrastructure to vaccinate millions of people, many physicians are concerned that the second dose of vaccine won’t be delivered in the prescribed three-to-four-week window. That booster shot is necessary for the T-cells to stimulate the memory B-cells to produce massive quantities of antibodies. If the booster isn’t given within the appropriate window, lower quantities of antibodies will be produced that may not provide as powerful protection from the virus. [Deep knowledge, daily. Sign up for The Conversation’s newsletter.]This article is republished from The Conversation, a nonprofit news site dedicated to sharing ideas from academic experts. It was written by: William Petri, University of Virginia. Read more:How mRNA vaccines from Pfizer and Moderna work, why they’re a breakthrough and why they need to be kept so coldCOVID-19 vaccines were developed in record time – but are these game-changers safe? William Petri receives research funding from the NIH, the Bill & Melinda Gates Foundation and Regeneron, Inc.
- Associated Press
A former teacher extradited from Israel after a six-year legal battle appeared in an Australian court Thursday to face child sex abuse charges. Malka Leifer, 54, appeared in Melbourne Magistrates Court by video link from a police station where she is in COVID-19 quarantine. Guards in the room with Leifer confirmed that the audio-visual link was working.
- The Independent
‘As exorcists will confirm, the demons are very good with electronic equipment,’ claims reverend John Zuhlsdorf
- The Telegraph
A doctor with terminal cancer killed a female paediatrician and then himself after taking hostages at a children's clinic in Austin, Texas. Dr Bharat Narumanchi held hostages in a five-hour siege before killing Dr Katherine Lindley Dodson. Narumanchi had applied for a volunteer position at the clinic a week ago and was declined. He later came back carrying a pistol, a shotgun and two duffel bags. Police spokesman Jeff Greenwalt said Narumanchi had recently been given "weeks to live" after a cancer diagnosis. He said: "The case as far as who did this is closed. We know who did it. And we know that there's no longer a threat to the public. But we really, really want to answer the question of why." Dr Lindley Dodson, 43, was beloved by patients and their families. Karen Vladeck, whose two children were among her patients, told the Austin American-Statesman: "You saw her at your worst when your kid was sick, and she just always had a smile on her face. "She made you feel like you were the only parent there, even though there was a line of kids waiting." During the siege a SWAT team used a megaphone to communicate with the armed doctor. A hostage negotiator shouted: "Your life is very important to me. And I know life is very important to you. "You don't deserve to go through this. For all you have done for others. That is why I want to help you work through this. You have saved a lot of lives." Police first sent in a robot and then officers went into the medical office where they found two bodies. They did not comment on how the two doctors died. A police spokesman said: "The SWAT situation has ended. Two subjects have been located and were pronounced deceased."
- Associated Press
At least two journalists tested positive for coronavirus after witnessing the Trump administration's final three federal executions, but the Bureau of Prisons knowingly withheld the diagnoses from other media witnesses and did not perform any contact tracing, The Associated Press has learned. The AP is not identifying the journalists, but has confirmed they both received positive coronavirus tests following the executions earlier this month at the Federal Correctional Complex in Terre Haute, Indiana. The Bureau of Prisons just completed a record number of executions under former President Donald Trump, more than any previous administration.
- CBS News
House Republican Leader Kevin McCarthy's warning comes as some of his colleagues are organizing an effort to oust Representative Liz Cheney.
- Yahoo News Video
China toughened its language toward Taiwan on Thursday, warning after recent stepped-up military activities near the island that "independence means war" and that its armed forces were taking action to respond to provocation and foreign interference.
A federal judge in Texas on Tuesday temporarily blocked a move by new U.S. President Joe Biden to halt the deportation of many immigrants for a 100-day period, a swift legal setback for his ambitious immigration agenda. U.S. District Judge Drew Tipton, an appointee of former President Donald Trump in the Southern District of Texas, issued a temporary restraining order that blocks the policy nationwide for 14 days following a legal challenge by Texas. The Biden administration is expected to appeal the ruling, which halts the deportation freeze while both parties submit briefs on the matter.
- The Telegraph
Europe’s press has again given wide-ranging coverage to the row between Britain and the EU over the supply of vaccines, with one paper saying that Boris Johnson’s “gamble” in getting a head-start on production had paid off. The EU has urged AstraZeneca to divert millions of doses from UK plants, but the British government has resisted those demands. Michael Gove, the Cabinet Office minister, told the BBC on Thursday: "The supplies that have been planned, paid for and scheduled should continue." Asked whether he would allow vaccines manufactured in the UK to be diverted to the EU, he said "no", adding that there must be no interruption to the British vaccination programme. AstraZeneca says it can only deliver the EU a fraction of the doses between now and March due to production problems at plants in Europe. De Standaard, a Belgian newspaper, said the success of the Prime Minister’s move was a source of great frustration to the French, in particular, who are lagging far behind in their vaccine programme. It suggested that Brexiteers would take heart from that because Paris had regularly taken a hardline stance in the Brexit negotiations. The Flemish newspaper said that Mr Johnson liked to take risks and in this case, as opposed to in Brexit, the gambit had worked. Another Belgian paper, Het Nieuwsblad, said the unprecedented public attacks by the European Commission were designed to bring AstraZeneca "to its knees". "These doses are crucial to give a long-awaited boost to slow European vaccination campaigns," the paper said. It quoted Hendrik Vos, a professor of European politics, who said the Commission wanted to prove the shortfall was not its fault.
- The Independent
Grandmother ‘overjoyed’ to be outside after receiving Covid-19 vaccine killed in Portland vehicle attack
Police have not released a motive in the attack
- Associated Press
A sea of tens of thousands of farmers riding tractors and horses stormed India’s historic Red Fort this week — a dramatic escalation of their protests, which are posing a major challenge to Prime Minister Narendra Modi's government. The AP explains what is at the heart of two months of demonstrations and what it means for Modi's government. Modi has billed the laws as necessary to modernize Indian farming.