How to fix the orphan drug problem driving up medical costs

How to fix the orphan drug problem driving up medical costs
Nicole Hassoun

An outdated law designed to spur drug development drives up the cost of new treatments, including those for Covid-19.

Continue reading

Latest Stories

  • Incoming Biden administration to migrant caravan: Don't come, you won't get in immediately

    "The situation at the border isn't going to be transformed overnight," a senior Biden transition official told NBC News in an exclusive interview.

  • GitHub apologizes for firing Jewish employee who warned of Nazis in U.S. Capitol: TechCrunch

    After a probe found "significant errors of judgment and procedure" in the termination of the employee, GitHub's head of human resources resigned, GitHub Chief Operating Officer Erica Brescia said on Sunday. "In light of these findings, we immediately reversed the decision to separate with the employee and are in communication with his representative," Brescia said in a blog https://bit.ly/2KnkVhI, adding that the company apologized to that employee.

  • Rand Paul Warns One-Third of Republicans Will Leave Party if GOP Senators Back Impeachment

    Senator Rand Paul (R., Ky.) warned Friday that one-third of Republican voters could leave the party if GOP senators vote in impeachment proceedings to convict President Trump. Paul made the comments in an interview on Fox News’ The Ingraham Angle. The senator’s remarks come amid an increasing divide between congressional Republicans who oppose impeaching the president and a smaller number who support the measure following the riots at the Capitol on January 6. Senate Majority Leader Mitch McConnell (R., Ky.) is reportedly hopeful that Republicans can use impeachment to purge Trump from the GOP, although he would need the support of at least 16 additional Republican senators to vote to convict. “Look, I didn’t agree with the [Capitol] fight that happened last week, and I voted against overturning the election, but at the same time, the impeachment is a wrongheaded, partisan notion, [and] if Republicans go along with it, it’ll destroy the party,” Paul said during the interview. “A third of the Republicans will leave the party,” Paul continued. “This isn’t about, anymore, the Electoral College, this is about the future of the party, and whether you’re going to ostracize and excommunicate President Trump from the party. Well, guess what? Millions of his fans will leave as well.” While a majority of Americans believe Trump should be removed from office immediately, just 17 percent of Republicans support expelling Trump from the presidency, according to an Axios–Ipsos poll released on Thursday. Support for Trump among Republicans has fallen since the Capitol riots; however, 60 percent believe the party should continue to follow Trump once he leaves office, an ABC News/Washington Post poll found.

  • Man arrested at DC checkpoint with loaded handgun and ‘unauthorised’ inauguration credentials

    Police discover more than 500 rounds of ammunition at checkpoint into security-heavy capital

  • Kevin McCarthy warned members to not call out colleagues by name, citing potential political violence

    Members of the House Republican Conference ignored leader Kevin McCarthy last week when he warned them against criticizing colleagues by name based on intelligence that doing so could trigger more political violence. Why it matters: McCarthy made clear that name-dropping opponents, instead of spelling out complaints in more general terms, can put a literal target on a politician, especially with tensions so high following the events of Jan. 6.Get smarter, faster with the news CEOs, entrepreneurs and top politicians read. Sign up for Axios Newsletters here.That's what happened to Rep. Liz Cheney, the GOP conference chairperson, after she said she would support impeaching President Trump. * She and several other members had to increase their security and take extra precautions because of death threats and other alarming warnings after their colleagues singled them out in their complaints.What McCarthy said: The House minority leader issued his warning during a conference call last Monday. He said his concern was driven by the FBI briefings he receives. * "It doesn’t matter which side of the position you were: I respect it, I respect why you did what you did. But what we are saying on television, when we say a member’s name. ... This is not the moment in time to do it." * "You can incite something else. The country is very divided and we know this. Let’s not put any member, I don’t care who they are Republican, Democrat or any person not even in Congress. Watch our words closely. I get these reports on a weekly basis. I’ve seen something I haven’t seen before.”Several minutes later, McCarthy repeated the message: “Emotions are high. What you say matters. Let’s not put other people in danger. Let’s watch what words we’re using and definitely not be using other members' names in any media.”Days later, some GOP members ignored him and openly criticized their colleagues * Rep. Adam Kinzinger tweeted that the name of his Republican colleague, Rep. Majorie Taylor Greene, "will be one forgotten by next January." * Rep. Lauren Boebart (R-Colo.) mocked Speaker Nancy Pelosi over the House's new mask fines.One of the most blatant attacks, leading to a media firestorm, was when several members of the House Freedom Caucus went after Cheney for voting to impeach Trump. * On the day of the vote, the members circulated a petition to remove her from her leadership role. * Cheney is now fielding a series of threats against her, many from fiery Trump supporters angered by her vote, a source with direct knowledge of the threat said. * “We don’t comment on security matters,” Cheney’s communications director, Jeremy Adler, told Axios.What we’re hearing: McCarthy's team told Axios he isn't looking for repercussions. Spokesman Matt Sparks said the leader wants to lower the temperature and is encouraging members to be mindful of the current environment.Be smart: sign up FREE for the most influential newsletter in America.

  • Tens of thousands evacuated amid Indonesia floods

    Tens of thousands of people have been evacuated and more than a dozen have been killed in recent days in flooding on Indonesia's Borneo island, officials said Sunday. National Disaster Mitigation Agency spokesperson Raditya Jati said floods brought by intense rains caused floodwaters as high as 3 meters (10 feet). As of Sunday, 39,549 people had been evacuated and at least 15 had been killed due to floods that affected 10 districts and cities in South Kalimantan province on Borneo island.

  • Biden will wait for recommendation on sharing secrets with Trump

    U.S. President-elect Joe Biden will wait for a recommendation from his intelligence advisers on whether to share classified information with President Donald Trump after the Republican leaves office, Biden's top aide said on Sunday. Ron Klain, the incoming White House chief of staff, made the comment after former principal deputy director of national intelligence, Sue Gordon, wrote an op-ed arguing against sharing such information with Trump once he has left the presidency.

  • GOP Sen. Ben Sasse warns "QAnon is destroying" the Republican Party "from within"

    Sen. Ben Sasse (R-Neb.) called on his Republican Party to rebuild itself and "repudiate the nonsense that has set our party on fire" in an in an op-ed for The Atlantic Saturday on the QAnon conspiracy theory.Why it matters: Many of the mob involved in the deadly Jan. 6 Capitol Hill riots wore items signaling their support for the far-right QAnon and a prominent member of the cult was among those arrested following the siege.Get smarter, faster with the news CEOs, entrepreneurs and top politicians read. Sign up for Axios Newsletters here. * Several Republicans who ran for Congress last year publicly supported or defended the QAnon movement or some of its tenets — something Sasee noted in his op-ed, headlined "QAnon is Destroying the GOP From Within." * Sasse blames the violence on "the blossoming of a rotten seed that took root in the Republican Party some time ago and has been nourished by treachery, poor political judgment, and cowardice."Driving the news: Sasse wrote in his op-ed that "until last week, many party leaders and consultants thought they could preach the Constitution while winking at QAnon." * "They can't," he added. "The GOP must reject conspiracy theories or be consumed by them. Now is the time to decide what this party is about." * Sasse criticized House Minority Leader Kevin McCarthy (R-Calif.) for not denouncing QAnon supporter Marjorie Taylor Greene (R-Ga.) when she was running for Congress in 2020. * "She's already announced plans to try to impeach Joe Biden on his first full day as president," Sasse wrote. "She'll keep making fools out of herself, her constituents, and the Republican Party."Worth noting: Sasse said before the House impeached President Trump for a second time he'd consider "definitely consider" any articles of impeachment against him over his conduct and comments at a rally before the riots. * The Nebraska senator criticized Trump's embrace of QAnon supporters last August, warning that Democrats could "take the Senate" this "will be a big part of why they won." * Months later, the Democrats went on to win control of the Senate.The bottom line: Sasse wrote that his party faces a choice when Trump leaves office: "We can dedicate ourselves to defending the Constitution and perpetuating our best American institutions and traditions, or we can be a party of conspiracy theories."Go deeper: * The Capitol siege's QAnon roots * House freshmen at war after Capitol siegeSupport safe, smart, sane journalism. Sign up for Axios Newsletters here.

  • 'Extreme urgent need': Starvation haunts Ethiopia's Tigray

    From “emaciated” refugees to crops burned on the brink of harvest, starvation threatens the survivors of more than two months of fighting in Ethiopia’s Tigray region. The first humanitarian workers to arrive after pleading with the Ethiopian government for access describe weakened children dying from diarrhea after drinking from rivers. A local official told a Jan. 1 crisis meeting of government and aid workers that hungry people had asked for “a single biscuit.”

  • Joe Biden preparing blizzard of executive orders for first days in office

    Joe Biden aims to hit the ground running with a blizzard of executive orders on his first day in office. Mr Biden plans to rejoin the Paris climate accord, end Donald Trump’s travel ban on several predominantly Muslim countries and order masks to be worn in federal buildings. The orders will represent the opening salvo of a flurry of activity over the first 10 days of the Biden administration, aimed at rolling back many of the policies introduced by Donald Trump. Mr Biden intends to introduce legislation for a $1.9 trillion relief package and immigration reform. His ambitious programme was outlined in a memorandum circulated on Saturday by Ron Klain, the incoming White House chief of staff. "During the campaign, President-elect Biden pledged to take immediate action to start addressing these crises and build back better," Mr Klain wrote. "As president, he will keep those promises and sign dozens of executive orders, presidential memoranda, and directives to Cabinet agencies in fulfilment of the promises he made." The 78-year-old incoming president will assume office with the country reeling from the coronavirus pandemic which has already claimed more than 395,000 lives and devastated the economy with 7.3 million people looking for work. A wave of lockdowns as the pandemic surged in recent months has seen millions more struggling as their working hours have been cut.

  • Israel may be starting to show 'herd effects' of Pfizer-BioNTech COVID-19 vaccine, expert suggests

    Israel has vaccinated at least 25 percent of its population against the coronavirus so far, which leads the world and makes it "the country to watch for herd effects from" the Pfizer-BioNTech COVID-19 vaccine, says infectious disease expert David Fishman. Recently, the case rate in Israel appears to have declined sharply, and while there could be a few reasons for that, it's possible the vaccination effort is beginning to play a role.> Israel's reproduction number appears to have declined rather sharply in recent days, with around 25% of the country vaccinated, and some additional percentage having at least partial immunity via prior infection. pic.twitter.com/sVyCYYd9dj> > — David Fisman (@DFisman) January 17, 2021One study from Clalit that was published last week reports that 14 days after receiving the first Pfizer-BioNTech shot, infection rates among 200,000 Israelis older than 60 fell 33 percent among those vaccinated compared to 200,000 from the same demographic who hadn't received a jab.At first glance, Fishman writes, that might seem disappointing since clinical trials suggested the vaccine was more than 90 percent effective. But he actually believes the 33 percent figure is "auspicious." Because vaccinated and non-vaccinated people are mingling, there could be "herd effects of immunization." In other words, when inoculated people interact with people who haven't had their shot, the latter individual may still be protected because the other person is. On a larger scale, that would drive down the number of infections among non-vaccinated people, thus shrinking the gap between the two groups' infection rates.> Estimated vaccine efficacy is a function of relative risk of infection in the vaccinated...when there is indirect protection via herd effects, we expect efficacy estimates to decrease because the risk among unvaccinated individuals declines.> > — David Fisman (@DFisman) January 17, 2021More data needs to come in, and Fishman thinks "we'll know more" this week, but he's cautiously optimistic about how things are going.More stories from theweek.com 5 more scathing cartoons about Trump's 2nd impeachment Trump's vaccine delay is getting suspicious The pandemic windfall

  • Convicted stalker kidnapped Pembroke Pines family and still has teen girl, cops say

    A man who did prison time for aggravated stalking and has convictions for domestic violence and violating a restraining order has an 18-year-old girl he has kidnapped at gunpoint, Pembroke Pines police said.

  • Distrust, division and doubt cloud Palestinian election call

    Beset by political infighting, split between three territories and distrustful of their institutions, many Palestinians are sceptical that their first national elections in 15 years will bring change - or even happen at all. President Mahmoud Abbas said on Friday that parliamentary and presidential elections would be held later this year in a bid to heal long-standing divisions. The announcement is widely seen as a gesture aimed at pleasing U.S. President-elect Joe Biden, with whom the Palestinians want to reset relations after they reached a low under Donald Trump.

  • Army IDs 1st Armored Division Staff Sergeant Found Dead at Fort Bliss Home

    The U.S. Army has identified a 1st Armored Division staff sergeant from Fort Bliss, Texas found dead at his home Thursday.

  • Congresswoman's spokesman quits less than 2 weeks into term

    The spokesman for Republican U.S. Rep. Lauren Boebert has quit less than two weeks after she was sworn into office, saying he felt like he need to due to the insurrection at the nation's Capitol.

  • After Trump, Biden aims to reshape the presidency itself

    When Joe Biden takes the oath of office Wednesday outside a wounded U.S. Capitol, he will begin reshaping the office of the presidency itself as he sets out to lead a bitterly divided nation struggling with a devastating pandemic and an insurrection meant to stop his ascension to power. Biden had campaigned as a rebuke to President Donald Trump, a singular figure whose political power was fueled by discord and grievance. The Democrat framed his election as one to “heal the soul” of the nation and repair the presidency, restoring the White House image as a symbol of stability and credibility.

  • Colombia's rapidly breeding 'cocaine hippos' must be stopped, scientists say

    Scientists say Colombia must cull its so-called “cocaine hippos” that roam the Magdalena river basin as they are breeding voraciously and are an increasing menace. The marshlands of Colombia have been home to these giant mammals since they were illegally imported in the late 1980s by the notorious drug lord, Pablo Escobar. When he was shot dead in 1993, the Colombian government took control of his extravagant estate, including his personal zoo. Most of the animals were shipped away, but four hippos were left to fend for themselves in a pond, and now there are dozens of them living in the wild. Although nobody knows exactly how many there are, estimates put the total number between 80 and 100, making them the largest invasive species on the planet. Scientists forecast that the number of hippos will swell to almost 1,500 by 2040. They conclude, that at that point, environmental impacts will be irreversible and numbers impossible to control. “Nobody likes the idea of shooting a hippo, but we have to accept that no other strategy is going to work,” ecologist Nataly Castelblanco-Martínez told The Telegraph.

  • Fauci: Two more Covid vaccines just ‘weeks’ away from US distribution

    Biden’s plan to get 100m Americans vaccinated in first 100 days is ‘doable,’ Dr Fauci says

  • Libya talks make progress towards new temporary government, U.N. says

    A Libyan political dialogue arranged by the United Nations has made progress towards agreeing a new transitional government to oversee the run-up to elections in December, the U.N. said on Saturday. Acting U.N. Libya envoy Stephanie Williams said the agreement represented the "best possible compromise" on the issue and could lead to the selection of a transitional government "in several weeks". Libya has been split since 2014 between rival factions in Tripoli, in the west, and Benghazi in the east.

  • Trump's presidency not just a blip in US foreign policy

    President-elect Joe Biden’s plan to scrap President Donald Trump’s vision of “America First” in favor of “diplomacy first” will depend on whether he's able to regain the trust of allies and convince them that Trumpism is just a blip in the annals of U.S. foreign policy. From Europe to the Middle East and Asia, Trump’s brand of transactional diplomacy has alienated friends and foes alike, leaving Biden with a particularly contentious set of national security issues. Biden, who said last month that “America's back, ready to lead the world, not retreat from it,” might strive to be the antithesis of Trump on the world stage and reverse some, if not many, of his predecessor’s actions.