Tennessee Titans quarterback Jake Locker is active and starting Sunday against the San Francisco 49ers.
Locker sprained his right hip and knee against the New York Jets on Sept. 29 and missed the last two games.
Ryan Fitzpatrick started the last two games for the Titans.
Locker completed 62.2 percent of his passes for 721 yards with six touchdowns and no interceptions in his first four games.
Also, rookie Brian Schwenke will make his debut at center while defensive end Derrick Morgan is out with a shoulder injury.