A report published by the CDC with the latest figures showed there were 759 flu deaths between 7 October and 23 December.
It also said since early December more than 100 people were dying every week from the flu and the death toll could increase as there has been a further rise in the number of hospital admissions.
This is more than double the number of flu deaths from the same period last year when there were only 322 reported fatalities, CBS News reported.
An increase in the number of reported cases of the flu during the winter is common and usually peaks around Christmas and New Year when more people are travelling and spreading illness.
In the UK, 149 people have so far died and last week 4,500 people were hospitalised, according to Public Health England fiures.
Some 120 flu deaths have been recorded in England, 21 in Scotland and eight in Northern Ireland. There is no precise data available for Wales.
The Catholic diocese of Down and Connor in Northern Ireland has temporarily banned its priests from shaking the hands of parishioners as they receive Holy Communion in favour of a “sign of peace” to avoid spreading the virus.
Meanwhile people are still being urged to get a flu jab to help protect vulnerable people.
A letter sent to every GP practice in England last week warned that up to three million high risk patients had yet to have the jab.
The flu virus mutates every year so even people who have had the vaccine in previous years need to be immunised against this latest strain.