But die-hard supporters aren't the only ones who have called for the Cecil B. DeMille award recipient to step into the political spotlight.
Even President Donald Trump once said he'd like to see Oprah in the White House -- as his very own veep.
In a 1999 interview with CNN's Larry King, a pre-presidential Trump admitted that Oprah would be his dream running mate if he were to ever seek election.
"I tell you, she's really a great woman. She is a terrific woman. She is somebody that is very special," Trump said.
"I mean, if she would ever do it. I don't know that she would ever do it," he continued. "She would be sort of like me. I mean, I have a lot of things going, she's got a lot of things going on ... that would be a pretty good ticket."
So, can we expect to see President Winfrey sitting in the West Wing any time soon?
According to Oprah's longtime partner, Stedman Graham, we just might.
"It's up to the people," Graham told The Los Angeles Times. "She would absolutely do it."
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- This article was initially published on AOL.com: Donald Trump floated the idea of a presidential run in 1999 — with Oprah as his vice president