The Indianapolis Colts announced Saturday that safety LaRon Landry and outside linebacker Bjoern Werner will not play Monday night's game at the San Diego Chargers.
Landry is out with an ankle injury and Werner has an injured foot.
Landry had 26 tackles in the first two games of the season but has not played since then. Delano Howell has played in place of Landry.
Werner, the Colts' first-round draft pick this year, has five tackles in four games as a backup.
Colts coach Chuck Pagano said fullback Stanley Havili (foot), defensive end Ricky Jean Francois (groin) and outside linebacker Erik Walden (elbow) are expected to play.