Christina Applegate Leaves NBC's Up All Night

Christina Applegate arrives as LG presents '20 Magic Minutes..A Family Celebration' at The Garden at Ascona Mansion in Los Angeles on June 23, 2012 -- Getty Premium

Christina Applegate is departing her NBC comedy, "Up All Night."

"It's been a great experience working on 'Up All Night', but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors," Christina said in a statement on Friday. "Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always."

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In Season 1 of the show, Christina played working mom Reagan Brinkley, who was a producer on a fictional talk show - "Ava" - hosted by Maya Rudolph's character. Season 2 changed things up with Maya's character now a former talk show host, and Christina's Reagan adjusting to being a stay-at-home mom.

The comedy also stars Will Arnett as Reagan's husband, Chris.

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NBC would not comment on the news, when contacted by Access Hollywood on Friday.

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