Bono asks the audience, "Imagine a man looking down on us from 200 miles up. Looking down at our beautiful crowded planet ... What would he say to us?"
On a ginormous screen, the face of Commander Mark Kelly, who is married to Giffords, beams in from outer space with the words to "Beautiful Day" floating in zero gravity all around him. Kelly commanded that last space flight of the Endeavour shuttle in May, and made time to record a message for U2.
Kelly speaks to Bono and fans: "Hello Seattle ... from the International Space Station." He then delivers a line from David Bowie's "Space Oddity": "I'm looking forward to coming home. Tell my wife I love her very much ... she knows."
See the video of this moving moment here.
U2 band members The Edge and Bono will appear at the "Decade of Difference" concert on Oct. 15.