EAST RUTHERFORD, N.J. (AP) -- Bills running back C.J. Spiller left the game against the Jets in the third quarter with a knee injury and will not return.
It was uncertain when Spiller was injured, but he had just 10 carries for 9 yards when he left.
Also, Bills cornerback Leodis McKelvin and Jets running back Chris Ivory left with hamstring injuries.
McKelvin was ruled out for the rest of the game, while Ivory was questionable.
McKelvin went down twice during the Jets' opening drive in the first quarter Sunday, grabbing at his right hamstring each time.
After the second, he slammed his helmet to the ground as he walked to the sideline. McKelvin was examined by trainers, and then watched from the sideline with his right leg wrapped in ice.
It was a tough blow to an already banged-up secondary for the Bills, who were without starting cornerback Stephon Gilmore and safety Jairus Byrd with injuries.
Ivory also left midway through the second quarter, and had 5 yards rushing before being checked out by trainers on the sideline.
Bills right guard Kraig Urbik left late in the second quarter with a knee injury, but returned to start the third quarter.
Buffalo defensive lineman Marcell Dareus left midway through the third quarter with an ankle injury, and was ruled out for the rest of the game.
AP NFL website: www.pro32.ap.org