Balotelli, 24, left Italy in a private jet at lunchtime on Friday and, provided he passes a medical, was due to be unveiled as a Liverpool player by the end of the day.
For Milan, the 20-million-euro ($27 million) sale is the latest confirmation that the one-time giant of Italian football has become a selling club. It has also left a huge gap in their forward line, little over a week from the closure of the transfer market.
Milan boss Filipo Inzaghi, who has already lost Brazilian playmaker Kaka to Major League Soccer (MLS) this summer, is reported to be pursuing FC Porto's highly-rated Colombian striker Jackson Martinez.
After scoring 46 goals in 60 appearances over the two seasons he has spent in Portugal, Martinez, 27, has attracted interest from a string of top clubs, including Arsenal and Chelsea, so there is no guarantee that Milan will succeed in bringing him to the San Siro.
Reports suggest Inzaghi is also looking at Torino and Italy winger Alessio Cerci. Also 27, Cerci is possibly a more realistic target given that Milan, who finished eighth in Serie A last season, cannot offer new recruits European football.
Neither Martinez or Cerci will come with Balotelli-sized salary expectations, which will be welcome news for Milan owner Silvio Berlusconi.
The media tycoon and former prime minister turns 78 next month and has been steadily scaling back his financial commitment to the seven-times European champions.
Balotelli is the latest in a string of top players to leave Milan in recent years.
Andrea Pirlo was allowed to go in 2011 because Berlusconi would not sanction any more than a one-year contract extension for the playmaker who has since helped Juventus to three consecutive titles. Zlatan Ibrahamovic and Thiago Silva departed for Paris Saint-Germain a year later.
It has been seen as significant that Berlusconi has sanctioned the sale of Balotelli for 20 million euros ($27 million), the same amount he paid for him in January 2013 when Manchester City were desperate to offload him.
Berlusconi's daughter, Barbara, revealed earlier this year that the family were seeking new investors who would be willing to buy a 30 percent stake in the club with the aim of restoring its financial firepower. To date there have been no indications of progress on that front.
- Will always walk alone -
The baggage of erratic, unpredictable behaviour that comes with Balotelli was reflected in the reaction to his departure.
A poll run on sports daily Gazzetta dello Sport's website suggested most readers were happy to see the back of him, with 83 percent of more than 2,500 respondents saying they were happy to see him return to England.
His departure also provoked much humorous comment on social media, with one Twitter user mocking up an image of the famous Abbey Road picture of the Beatles on a pedestrian crossing with Balotelli parked on it in his red sports car.
Another Twitter-wit observed: "Balotelli leaving Italy: it's not one to add to the brain drain list."
Former Italy striker Christian Vieri also weighed in, tweeting that Milan CEO Adriano Galliano had pulled off the greatest transfer "coup" in the club's history.
In a more serious commentary on Balotelli joining the fourth major club of his career at the age of 24, La Gazzetta said Italy would miss its prodigal son.
But the daily also suggested he could struggle to settle on Merseyside, far from his Italian family and the baby daughter he has with a former girlfriend.
"The Kop will sing 'You'll Never Walk Alone' to him ... but Mario, who seems incapable of putting down roots, will always walk alone," Gazzetta predicted. "He is on an eternal odyssey."