Christina Applegate Quits 'Up All Night'

Krista Wick
ET Online
Christina Applegate Ties The Knot!

Due to creative differences, Up All Night star Christina Applegate has announced her plans to leave the NBC sitcom.

Pics: Star Sightings

"It's been a great experience working on Up All Night, but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors," Applegate tells Deadline. "Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always."

Applegate's departure is believed to be linked to the show's plans to switch from single-camera to multi-cam filming format and begin taping in front of a live studio audience.

Related: Christina Applegate Wants 'One More' Baby

Up All Night, also starring Maya Rudolph and Will Arnett, just wrapped it's second season.

They Dated?! Surprising Celebrity Hookups
Star Sightings: Celebrity Candids
Are These Celebs Too Tan?! Cast Your Vote!