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The personalities of the Harry and Sally characters were based, in part, on director Rob Reiner and screenwriter Nora Ephron.

In the introduction to the book adaptation of the 'When Harry Met Sally...' screenplay, Ephron (who passed away in 2012) explained that she based Harry’s proclivity toward pessimism on Reiner’s own depressive streak. As for the always-happy, high-maintenance Sally, Ephron needed to look no further than the nearest mirror. “I began with a Harry, based on Rob,” she writes. “And because Harry was bleak and depressed, it followed absolutely that Sally would be cheerful and chirpy and relentlessly, pointlessly, unrealistically, idiotically optimistic. Which is, it turns out, very much like me.”

10 Things You Didn't Know About 'When Harry Met Sally...'

Yahoo MoviesJuly 10, 2014

Twenty-five years ago, on July 12, 1989, the meaning of the phrase “I’ll have what she’s having” changed forever. 'When Harry Met Sally…' opened in select theaters on that day, and created an indelible template for every romantic comedy that would follow it. With its tennis-volley-quick exchanges between stars Meg Ryan and Billy Crystal, a vibrant New York-in-autumn color palette, and an undercurrent of sunny optimism, 'When Harry Met Sally...' became the movie that every rom-com since has tried to match, usually with minimal success. To celebrate the 25th anniversary of Harry Burns and Sally Albright, here’s a list of things you might not know, including all those alternate titles and which son of a U.S. president broke Sally's heart.