| SS | 10-day-dl (The Boston Red Sox placed INF Romy González on the 10-day injured list with a hamstring strain.) | |
| 2B | 10-day-dl (The Boston Red Sox placed INF Vaughn Grissom on the 10-day injured list with a hamstring injury.) | |
| LF | 10-day-dl (Tyler O'Neill is not in the starting lineup for Thursday's game (May 30) against the Tigers.) | |
| LF | 10-day-dl (The Boston Red Sox placed OF Masataka Yoshida on the 10-day injured list with a left thumb strain.) | |
| 1B | 60-day-dl (The Boston Red Sox transferred INF Triston Casas to the 60-day injured list with a rib strain.) | |
| P | 60-day-dl (The Boston Red Sox transferred RHP Garrett Whitlock to the 60-day injured list with an oblique strain.) | |
| P | 15-day-dl (The Boston Red Sox placed RP Isaiah Campbell on the 15-day injured list.) | |
| SS | 60-day-dl (The Boston Red Sox placed INF Trevor Story on the 60-day injured list with a left shoulder dislocation.) | |
| P | 60-day-dl (The Boston Red Sox placed RHP Liam Hendriks on the 60-day injured list as he recovers from Tommy John surgery.) | |
| P | 60-day-dl (The Boston Red Sox placed LHP Chris Murphy on the 60-day injured list with a left UCL sprain.) | |
| P | 15-day-dl (The Boston Red Sox placed RHP Bryan Mata on the 15-day injured list with a right hamstring strain.) | |
| P | 60-day-dl (The Boston Red Sox placed RHP Lucas Giolito on the 60-day injured list.) | |