On Will & Grace, Karen's beloved maid, Rosario died unexpectedly from a heart attack. Rosario was played by Shelley Morrison who retired from acting and opted not to return to the sitcom's revival so the writers decided to give her character the send off she deserved.
A doctor delivered the news to Karen at a hospital waiting room saying, "I'm very sorry to tell you that Rosario is gone." Karen quipped, "Gone? Where'd she go this time? Underground maids' fight club that I don't know about?"
Karen, played by Megan Mullally, processed the death of her best friend as one might expect, through drinking, ignoring her emotions and making Jack sing and dance for her.
Karen and Rosario had a hilariously tumultuous relationship throughout the series. But Rosario was also Karen's best friend and she had her own way of processing Rosario's death.
In the end, Will was able to get Karen off of her bar stool and back to the church to give Rosario a sweet farewell. She went up Rosario's coffin and said, "Sorry I wasn't here, but come on, what the hell was I gonna say? She was my maid? She was my sparring partner? She was my best friend? You were my everything, Rosario Yolanda Salazar."