In the quest for smoothing wrinkles and plumping lax skin, going under the needle (whether for neuromodulator or filler) reigns supreme. That said, if you wince at the thought of sharp objects or don't have hundreds (thousands!) to drop on in-office treatments, there are pain-free, subtle, and (relatively) inexpensive topical solutions that can certainly help. "The best line-fighting creams are those that help build our skin's own building blocks, namely collagen and elastin fibers," explains Deanne Robinson, a Connecticut-based dermatologist. For instance, she recommends topical retinoids, peptides, and growth factors to help support skin cell turnover, increase collagen fibers, and hydrate the skin to help reduce the appearance of fine lines. Below, 15 products (moisturizers, serums, and treatments) guaranteed to help iron out lines and fill in creases — no needle required.