Watch: Chris Stapleton serenades John Stamos on 'Jimmy Kimmel Live' in hilarious performance

On Wednesday night, Chris Stapleton hit the stage at "Jimmy Kimmel Live!" for a game of Wing It & Sing It, where he sang lyrics he'd never seen on the fly. Little did he know the performance would include a surprise appearance from none other than John Stamos.

Stapleton also performed his song "It Takes a Woman," which he had never performed live before, on the show's outdoor stage and sat down with Kimmel to chat about his career and whiskey brand.

"I was very tickled to learn that you're a fan of the show 'Full House,' or at least you were when you were a kid," Kimmel said to Stapleton before explaining the rules of the singing game.

"Sure. Yeah," Stapleton responded.

"That is the theme for our song tonight," Kimmel said.

"We've written lyrics, and these are lyrics that Chris has not seen ... now the music is gonna be up to you," Kimmel added. He said that Stapleton would play the guitar, make up a melody and sing the never-before-seen cue card lyrics as he unveils them one by one.

Stapleton began singing the cue cards in his recognizable gritty manner while strumming underneath.

"I've sung many songs about folks in my life / My family, my band, my friends and my wife / But the one human being that I love the most / Is an American treasure named John," and then said into the mic, "John Stamos."

On the screen behind them, a large image of Stamos appeared as Kimmel and Stapleton cracked up.

And from there on out, the ballad was an homage to the California-born "Full House" actor.

The song quipped on Stamos' Greek ethnicity and good looks. At one point, the screen showed an image of Stapleton's face cropped onto both Olsen twins, fellow "Full House" stars, alongside Stamos.

Stapleton sang, "With a sweet impish grin, those dimples, that chin / Those pretty green eyes, those shoulders, those thighs / An incredible bod on my Greek golden god. ..."

The line that really got Stapleton laughing, almost unable to keep singing, was "I'd give my left nut to be part of his squad."

Throughout the song, Stapleton's earnest and soulful voice impressed, alongside his musical improvisation skills.

Toward the end of the tune, the whole crowd sang Stamos' name together three times and he appeared in the studio, sauntering out in a white suit, red sunglasses and a Chris Stapleton T-shirt.

Stapleton beamed and gave Stamos a hug before serenading him with a final few lines.

The song ended with more hugs and an image on the back wall of Stamos and Stapleton in a red heart together with "BFF" written on it.

Through the clever cue cards and lyrical game, perhaps Jimmy Kimmel inspired a new budding friendship between the actor and country singer this Wednesday evening.

This article originally appeared on Nashville Tennessean: Chris Stapleton serenades John Stamos on Jimmy Kimmel's show | Watch