U2 Pays Tribute to Sinead O'Connor with 'Nothing Compares 2 U' at Las Vegas Residency

The Irish rock band kicked off their U2:UV 'Achtung Baby' Las Vegas residency at The Venetian's new venue Sphere on Friday

U2 took a moment out of their Las Vegas residency to pay tribute to the late Sinead O’Connor.

During their Saturday concert at the new Sphere venue in Vegas, the rock band broke into a snippet of O’Connor’s 1990 song “Nothing Compares 2 U,” honoring the singer who also hailed from the group’s native Ireland and died at age 56 in July. Fans captured footage of the heartfelt tribute.

Related: U2 Begins Las Vegas Residency at Technologically Advanced Sphere Venue: 'What a Fancy Pad'

The band featuring Adam Clayton, Bono, the Edge and Larry Mullen Jr. honored the singer-songwriter while playing their hit “With or Without You.” After Bono, 63, sang the final verse of the Grammy winners’ emotional fan-favorite, the song warped into the classic O’Connor track.

“Nothing compares to you,” the frontman repeated, while keeping his gaze glancing upwards. Moments after the song concluded, the vocalist continued looking peacefully up and outward at the animal designs in a pink hue that covered the interior of the spherical space.

Bryan Adams, Melissa Etheridge, and More Pay Tribute to Sinéad O'Connor: 'What a Loss'

The “Beautiful Day” band previously spoke about the death of the singer, whose death is currently being investigated with an autopsy after no medical cause was given. In July, they shared a photo of the artist and activist on Instagram and in the caption quoted the lyrics of her 1986 collaboration with their guitarist The Edge, 62, “Heroine.”

The group wrote, “Touch these eyes with a broken smile, Touch my mouth with your furrowed brow, Lift my heart, heal my shame , Lead me into rest again .. Heroine.. Rest In Peace Sinéad.”

Members of U2 including Adam Clayton, U2 and The Edge also mourned O’Connor as she was laid to rest in Bray, Country Wicklow, Ireland with a ceremony on Aug. 8.

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Related: Unreleased Sinéad O’Connor Song Debuts in BBC Show Months After Her Death: 'She Would Have Been Proud'

The Rock and Roll Hall of Famers began their U2:UV Achtung Baby Las Vegas residency at The Venetian’s new, technically advanced venue Sphere on Friday. They became the first group to ever perform in the new space, which sits inside a 366-foot-tall orb just east of the Vegas Strip and features 6K wraparound LED screen, 167,000 speakers and more.

The show marked the rockers’ first show in four years. Throughout the set they powered through 22 of their hits, including "One," "With or Without You" and "Where the Streets Have No Name."

A handful of celebrities were in attendance for the opening night, including Jon Hamm, Elizabeth Banks, Snoop Dogg, Dr. Dre, Orlando Bloom and Paul McCartney.

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