We were introduced to a new breed of bad guys on The Flash, starting with a bio-cybernetics hacker named Kilg%re.
Kilg%re was systematically killing off researchers he had worked with and who had stolen his virus coding.
Kilg%re was extremely dangerous because he possessed the meta ability to control anything technological. This enabled him to take over elevators, cars, and even Flash's fancy new computerized suit.
After capturing Kilg%re, Barry learned that his meta powers did not come from the particle accelerator explosion like Barry's.
While Barry doesn't know it yet, it appears as thought The Thinker had a hand in creating evil new metahumans.