In an exclusive interview with Oprah Winfrey in San Francisco at her 2020 Vision tour, "The Talk" hosts Sharon Osbourne and Carrie Ann Inaba ask Winfrey about her most memorable moments with guests thus far. "Every city has been different," says Winfrey. "Each person brings their own magic. You know, Michelle Obama is as authentic as they come. She is like the roots of the tree. And so, everything that she allows people to see comes from this huge space of authenticity. The Rock [Dwayne Johnson] was so vulnerable, because I interviewed him on a Saturday, he had buried his father on a Tuesday. So he comes with all of the that. Amy Schumer texted me two days before saying, 'Can I wear my sweats because I don't even feel like getting dressed.' Yes, come as you, everyone is going to accept you. Lady Gaga was phenomenal, because she allowed us to know that mental illness, the way everybody speaks about mental health... She allowed us to see how real it is by actually naming her medication."