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David Livingston/Getty; Chris Jackson/Getty Oprah Winfrey; Meghan Markle and Prince Harry
Just one day after Meghan, 39, and Prince Harry, 36, announced they are expecting their second child, CBS revealed that Oprah is going to have an "intimate conversation" with the couple for a 90-minute primetime special airing Sunday, March 7.
"Winfrey will speak with Meghan, The Duchess of Sussex, in a wide-ranging interview, covering everything from stepping into life as a Royal, marriage, motherhood, philanthropic work to how she is handling life under intense public pressure," CBS said in a statement. "Later, the two are joined by Prince Harry as they speak about their move to the United States and their future hopes and dreams for their expanding family."
Related: Meghan Markle Wins Privacy Case Agains UK Tabloid
PEOPLE Senior Editor Michelle Tauber joins PEOPLE Every Day to break down Harry and Meghan's announcement that they're expecting baby No. 2! Listen here and subscribe!
Misan Harriman Prince Harry and Meghan Markle
Ian West - WPA Pool/Getty Oprah Winfrey at Meghan Markle and Prince Harry's wedding
In addition to attending Meghan and Prince Harry's May 2018 wedding at Windsor Castle, Oprah is also one of the couple's neighbors in their Montecito, California neighborhood, where they moved this past summer.
In December, Oprah shared an Instagram video in which she unpacks a "basket of deliciousness" of Clevr Blends goodies from "my neighbor 'M.' " A spokesperson for Meghan confirmed to PEOPLE that she had "made her first private investment" in the woman-led wellness firm.
Oprah is also teaming up with Prince Harry for a mental health docuseries for Apple TV+. In a 2019 interview with podcast host and journalist Bryony Gordon, Harry said the series — which will premiere this spring — will unveil examples of "human spirit fighting back from the darkest places."
"When I did your podcast two years ago the response made me realize what an impact sharing my story could have, and what an impact other stories can have for so many who are suffering silently," Harry told Gordon. "If the viewers can relate to the pain and perhaps the experience, then it could save lives, as we will focus on prevention and positive outcomes."
Shutterstock Meghan Markle and Prince Harry attending the Commonwealth Day Service in the U.K. in March 2020.
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Harry also revealed that he and Oprah have had many meetings and "are assembling subject matter experts" to guide the series.
"The facts and science exist and we deserve to know it all," he said.