See Ginnifer Goodwin as Jackie O in 'Killing Kennedy' [Exclusive Photo]

The "Once Upon a Time" actress will star opposite Rob Lowe's JFK.

"Once Upon a Time" princess Ginnifer Goodwin will play the queen of Camelot this fall, when she plays first lady Jackie Kennedy in National Geographic Channel's upcoming docudrama "Killing Kennedy."

Goodwin, who looks strikingly like the stylish and elegant Jackie O in the photo above, will star opposite Rob Lowe as John F. Kennedy in the movie, which unfolds the story of Kennedy's 1963 assassination, adapted from the best-selling book of the same name by Bill O'Reilly and Martin Dugard.

[Photo: First Look at Rob Lowe as JFK: Yay or Nay?]

The film, which will premiere on the cable network in November to coincide with the 50th anniversary of JFK's death, began production this week in Virginia.

Additional cast members include "Gossip Girl" alum Michelle Trachtenberg as Marina Oswald, and Will Rothhaar as her husband, alleged Kennedy assassin Lee Harvey Oswald.