First Look at Rob Lowe as JFK: Yea or Nay? [Photo]

He's already been in the fictional White House on "The West Wing," and now Rob Lowe will be in the real White House, as the actor portrays America's 35th president, John F. Kennedy, in National Geographic Channel's upcoming drama "Killing Kennedy."

As seen in the photo above, Lowe re-creates an iconic pose from JFK's official White House portrait. Lowe started production this week in Virginia on the NatGeo film — based on the best-selling book by Bill O'Reilly and Martin Dugard — which will air in November, to coincide with the 50th anniversary of the Nov. 22, 1963 assassination of Kennedy.

Joining the actor in the movie will be "Once Upon a Time" star Ginnifer Goodwin as Jacqueline Kennedy, "Gossip Girl" alum Michelle Trachtenberg (in her first Russian-speaking role) as Marina Oswald, and Will Rothhaar as Lee Harvey Oswald.

[Related: Michelle Trachtenberg Talks About Her Upcoming Role as Lee Harvey Oswald's Wife in 'Killing Kennedy']

The JFK project is Lowe's second National Geographic Channel project of the year. He also narrated the network's April miniseries, "The '80s: The Decade That Made Us," which will spawn a sequel covering the 1990s next year.

[Related: Rob Lowe Suffered Migraines to Transform His Handsome Face for 'Behind the Candelabra']

"Killing Kennedy" is also Lowe's second big made-for-TV movie of the year, following the HBO Liberace movie "Behind the Candelabra." Lowe played real-life plastic surgeon Jack Startz, who not only performed a major makeover on Liberace, but also performed procedures to make the piano-playing superstar's much-younger lover look just like Liberace.

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