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Despite creating three COVID-19 vaccines in less than a year, America's fragmented health system doesn't offer a simple way to sign up to get a shot.
At least 13 people, 10 of them Mexican nationals, were killed on Tuesday when a tractor-trailer slammed into a Ford Expedition crammed with 25 adults and children in the dusty farming community of Holtville near the U.S.-Mexico border, officials said. Handmade wooden crosses stretched in a line across a patch of dry grass and dirt next to the highway, and a seat covered in what appeared to be blood lay near the SUV, as the desolate highway remained closed Tuesday afternoon. The white tractor trailer cab with yellow trim was still smashed into the wrecked side of the maroon SUV.
When the 'Punky Brewster' star embarked on a new documentary, she found that confronting her past, including surviving sexual assault, was the only way forward.
Meghan, Britain's Duchess of Sussex, was awarded 450,000 pounds ($630,000) on Tuesday as a provisional payment towards her legal costs after she won a privacy claim against the Mail on Sunday which had printed extracts of a letter she wrote to her father. Last month, a judge at London's High Court ruled the tabloid had breached her privacy and infringed her copyright by publishing parts of the five-page letter she wrote to her father, Thomas Markle, who she fell out with on the eve of her wedding to Queen Elizabeth's grandson, Prince Harry. Judge Mark Warby ruled in her favour without holding a trial, saying the articles were a clear breach of privacy after the paper argued the duchess had intended the letter's contents to become public and it formed part of a media strategy.
"Like, there are five people dead, two that took their own life on top of that, as a result of what you did," Kinzinger said of Hawley.
In the wake of J.K. Rowling's transphobic remarks, an upcoming "Harry Potter"-themed video game will allow users to play as trans witches and wizards.
A viral TikTok pointed out an error with characters like Harry Potter, Hermione Granger, and Ron Weasley during a scene in the third movie.
Biden's White House has essentially leaned on the importance of the diplomatic relationship with Saudi Arabia in defense of its actions.
President Joe Biden's pick to head the Office of Management and Budget, Neera Tanden, has withdrawn her nomination after she faced opposition from key Democratic and Republican senators for her controversial tweets. Thirteen of the 23 Cabinet nominees requiring Senate approval have been confirmed, most with strong bipartisan support. “Unfortunately, it now seems clear that there is no path forward to gain confirmation, and I do not want continued consideration of my nomination to be a distraction from your other priorities,” Tanden wrote in a letter to Biden.
The United States on Tuesday imposed sanctions to punish Russia for what it described as Moscow's attempt to poison opposition leader Alexei Navalny with a nerve agent last year, in President Joe Biden's most direct challenge yet to the Kremlin. The sanctions against seven senior Russian officials, among them the head of its FSB security service, and on 14 entities marked a sharp departure from former President Donald Trump's reluctance to confront Russian President Vladimir Putin.
Negotiations over President Joe Biden's $1.9 trillion COVID-19 relief bill go into overdrive this week as the U.S. Senate begins debate over the sweeping legislation and lawmakers jockey to include pet projects, while tossing others overboard. Senator Angus King, an independent aligned with Biden's Democrats, has been pushing for billions of dollars to expand high-speed broadband service in rural areas - an idea that could attract Republican support. But Democrats should not expect much, if any, Republican backing for the entire bill.
The comic legends told Jimmy Kimmel that Louie Anderson was cast in the classic 1980s comedy because he was one of three names given to them.
Will Cowboys use money they could potentially save by not caving into Prescott’s demands on building the team around him? The proof is not in the pudding.
Pennsylvania's Republican Party has expressed its disapproval of U.S. Sen. Pat Toomey over his vote to convict Donald Trump during the former president’s second impeachment trial, while stopping short of issuing the more serious — albeit still symbolic — censure that some members had pushed for. The vote counting wrapped up late Monday night, completing a five-hour remote video meeting last week that had to be continued because of technical problems, state committee members said. The vote count was 128-124, with 13 abstaining, to approve a statement expressing disappointment with fellow Republican Toomey, but not a censure, state committee members said.
Joe Exotic of “Tiger King" fame has found new attorneys who say they plan to file a motion for a new trial in a matter of months. Joe Exotic, whose real name Joseph Maldonado-Passage, was sentenced in January 2020 to 22 years in federal prison for violating federal wildlife laws and for his role in a failed murder-for-hire plot targeting his chief rival, Carole Baskin, who runs a rescue sanctuary for big cats in Florida. Baskin was not harmed.
The Philippine president has dismissed his former ambassador to Brazil after she was seen on video physically abusing a Filipino member of her household staff. President Rodrigo Duterte said Monday night he had approved a recommendation to fire Marichu Mauro, revoke her retirement benefits and disqualify her from public office for life. The Department of Foreign Affairs in Manila said at the time that the unidentified victim had returned to Philippines and that it was trying to reach her amid an investigation.
Carl Court/GettyBy William G. Bain, Georgios D. Kitsios, and Tomeka L. SuberA year ago, when U.S. health authorities issued their first warning that COVID-19 would cause severe “disruption to everyday life,” doctors had no effective treatments to offer beyond supportive care.There is still no cure, but thanks to an unprecedented global research effort, several treatments are helping patients survive COVID-19 and stay out of the hospital altogether.COVID-19 treatments target two broad problems: the coronavirus’s ability to spread through the body, and the damage caused by the body’s immune system response. When the virus enters the body, it takes over cells and uses them to replicate itself. In response, the body sends inflammatory signals and immune cells to fight the virus. In some patients, that inflammatory response can continue even after the virus is under control, leading to damage in the lungs and other organs.The best tool is prevention, including using face masks and vaccines. Vaccines train the immune system to fight off attackers. With less risk of an uncontrolled infection, they can cut the risk of death from COVID-19 to near zero. But vaccine supplies are limited, even with a third vaccine now authorized for U.S. use, so treatments for infected patients remain crucial.This Drug Is a Staple of COVID Treatment. Should It Be?As doctors who work with COVID-19 patients, we have been following the drug trials and success stories. Here are six treatments commonly used today for COVID-19. As you’ll see, timing matters.Keeping you out of the hospitalTwo promising types of treatments involve injecting antiviral antibodies into high-risk COVID-19 patients before the person becomes severely ill.Our bodies naturally create antibodies to recognize foreign invaders and help fight them off. But natural antibody production takes several days, and SARS-CoV-2—the coronavirus that causes COVID-19—replicates fast. Studies show that injecting patients with antibodies soon after symptoms begin can help protect patients against serious infection.Monoclonal antibodies: These lab-engineered antibodies can bind to SARS-CoV-2 and prevent the virus from entering cells and infecting them. They include Bamlanivimab and the combined therapy casirivimab/imdevimab developed by Regeneron. The U.S. Food and Drug Administration granted emergency use authorization for these therapies because they have been found to protect high-risk patients from hospitalization and death. Once patients are sick enough to need hospitalization, however, studies haven’t found a proven benefit from them.Convalescent plasma: Another way to deliver antibodies involves blood drawn from patients who have recovered from COVID-19. Convalescent plasma is primarily given in research settings because the clinical evidence so far is mixed. Some trials show benefits early in the disease. Other studies have not shown any benefit in hospitalized patients.There may be a role for convalescent plasma as a supplemental therapy for some patients because of the growing threat of mutated SARS-CoV-2 variants, which may evade monoclonal antibody therapy. However, careful research is necessary.If you are hospitalizedOnce patients become so sick that they have to be hospitalized, treatments change.Most hospitalized patients have difficulty breathing and low oxygen levels. Low oxygen occurs when the virus and corresponding immune response injure the lungs, resulting in swelling in lung air sacs that restricts the amount of oxygen getting into the blood. Patients hospitalized with COVID-19 usually need supplemental medical oxygen to help them breathe. Doctors frequently treat patients on oxygen with the antiviral agent remdesivir and anti-inflammatory corticosteroids.Remdesivir: Remdesivir, originally designed to treat hepatitis C, stops the coronavirus from replicating itself by interfering with its genetic building blocks. It has been shown to shorten the length of hospital stays, and doctors may prescribe it to patients on oxygen shortly after arrival in the hospital.Chris Christie Says He’s Out of the Hospital After Week-Long Stay for COVID-19Corticosteroids: Steroids calm the body’s immune response and have been used for decades to treat inflammatory disorders. They are also widely available, cheap and well-studied medications, so they were among the first therapies to enter clinical trials for COVID-19. Several studies have shown that low-dose steroids reduce deaths in hospitalized patients who are on oxygen, including the sickest patients in the intensive care unit, or ICU. Following the findings of the landmark RECOVERY and REMAP-CAP COVID-19 studies, steroids are now the standard of care for patients hospitalized with COVID-19 who are treated with oxygen.Blood thinners: Inflammation during COVID-19 and other viral infections can also increase the risk of blood clots, which can cause heart attacks, strokes and dangerous clots in the lungs. Many patients with COVID-19 are given the blood thinners heparin or enoxaparin to prevent clots before they occur. Early data from a large trial of COVID-19 patients suggests that hospitalized patients benefit from higher doses of blood thinners.Some patients with COVID-19 become so sick that they need an ICU for high levels of oxygen support or a ventilator to help them breathe. There are several therapies available for ICU patients, but ICU patients have not been found to benefit from high doses of blood thinners.Treating the sickest patientsICU patients with COVID-19 are more likely to survive if they receive steroids, studies have found. However, low-dose steroids alone may not be enough to curb excessive inflammation.Tocilizumab: Tocilizumab is a lab-generated antibody that blocks the interleukin-6 pathway, which can cause inflammation during COVID-19 and other diseases. New results from the REMAP-CAP trial that have not yet been peer-reviewed suggest that a single dose of tocilizumab given within one to two days after being placed on respiratory support reduced the risk of death in patients already receiving low-dose steroids. Tocilizumab has also been shown to benefit patients with high levels of inflammation in early results from another trial.These innovative therapies can help, but careful supportive care in the ICU is also crucial. Decades of extensive research have defined core management principles for helping patients with severe lung infections who need ventilators. These include avoiding underinflation and overinflation of the lung by the ventilator, treating pain and anxiety with low levels of sedative medications, and periodically placing certain patients with low oxygen levels on their belly, among many other interventions. The same key principles likely apply to patients with COVID-19 to help them survive and recover from a critical illness that can last weeks or months.Medical progress since the start of the pandemic has been awe-inspiring. Doctors now have vaccines, antiviral antibodies for high-risk outpatients and several treatments for hospitalized patients. Continued research will be crucial to improve our ability to fight a disease that has already claimed more than 2.5 million lives worldwide.William G. Bain, Georgios D. Kitsios, and Tomeka L. Suber are assistant professors of medicine at the University of PittsburghRead more at The Daily Beast.Get our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.
Stocks on Wall Street ended Tuesday lower, a day after a blockbuster rally that saw the S&P 500 have its best day since June. The Dow dropped nearly 150 points while the S&P also fell.And the Nasdaq lost about 1.7% as Apple, Facebook, Tesla and other big technology names tumbled.The tech-heavy index's fall came as investors continue to rotate out of stocks that outperformed due to the coronavirus pandemic and into others viewed as likely to do well as the economy recovers, such energy and travel companiesNicholas Colas of DataTrek Research says - given history - the recent volatility in markets is par for the course."This one is playing very much true to form with past cycles, we tend to get initially a big surge off the bottom when we first see fiscal stimulus, we got all of that last year. It was a little bit heavily skewed towards technology because of the unique nature of what happened with the pandemic, but it is the kind of classic lift off the bottom that we always get. At this point in the cycle, call it six to 12 to 10, even a year on from the bottom, we do get these first rumblings of inflation that begin to lift interest rates and the market begins to go a little bit wobbly. The same exact thing happened virtually to the day during the 2010 recovery, after the '09 crisis.Stocks on the move included Target, which said it will invest $4 billion annually over the next several years as the big box retailer upgrades stores and strengthens its online business. Shares are up sharply over the past year but fell nearly 7% on Tuesday on the expected hit to margins.Meanwhile, mortgage provider Rocket Companies bucked the trend, skyrocketing as much as roughly 70 percent, as the heavily shorted stock drew interest on Twitter and Reddit’s popular WallStreetBets.
DANIEL LEAL-OLIVAS / Getty ImagesPrince Harry and Meghan Markle are being urged by some commentators in the U.K. to ask CBS to postpone the airing of its Oprah Winfrey interview, in which they are expected to mount a stinging attack on the royal family, as concern mounts over Prince Philip’s prospects of beating an infection.Prince Harry Tells Oprah He Left the Royals Because He Feared Meghan Markle Would Suffer Like Princess Diana Philip, 99, was moved to a specialist heart hospital on Monday and royal sources have been quoted by British newspapers saying the family is “pretty appalled” at the idea of the interview, which Oprah has said sees Meghan saying “pretty shocking things” being broadcast while Philip is so unwell.Penny Junor, author of Prince Harry, Brother, Soldier, Son, told The Daily Beast that airing the interview while Prince Philip was undergoing very public health travails risked making the interview look inappropriate, saying, “Anything could hijack this interview. Philip is ill. He is 99 and could die at any time. They were not to know he would get ill, but it could be seen to be the wrong time. But I doubt it is in their gift to postpone the interview. The control is in the hands of CBS and Oprah.”Robert Lacey, historical consultant for The Crown and author of the definitive royal biography Majesty, told The Daily Beast, “I think it would be a marvelous turnaround for Harry’s image if he took the brave step of canceling the whole thing this weekend—or, if that’s not practical, postponing it at least.”Royal commentator and former editor of Who’s Who Richard Fitzwilliams said it would “surely be appropriate” to postpone the interview.He told MailOnline, “Oprah is their friend and neighbor and would undoubtedly comply if asked and the gesture would I am sure be appreciated by the royal family. If an interview has been extended, as this recently has, it can also be postponed, as this undoubtedly should be.” Royal biographer Robert Jobson told the Mail, “With the Duke of Edinburgh clearly very unwell, the fact that the couple plan to go ahead with airing their self-indulgent, no-holds-barred interview with chat show queen Oprah Winfrey makes them appear heartless, thoughtless, and supremely selfish.“For U.S. broadcast network CBS, this interview is a coup, all about securing big viewing figures and big advert sales around the airing of their exclusive interview. So even if they wanted to, Harry and Meghan probably couldn’t dictate terms to Oprah Winfrey and the network now. Too much has been invested.”A TV industry insider told the Mirror, “CBS has sold millions of dollars worth of advertising around the interview, but bosses are aware of the delicacy of the Duke’s health. They have no loyalty to the royal family, although some feel as though they do to Harry and Meghan. For it to run if Philip’s condition worsened would be like setting off a diplomatic bomb. It would be grossly insensitive and hugely disrespectful.”Read more at The Daily Beast.Get our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.