Kirstie Alley, the star of Cheers and Drop Dead Gorgeous, has died. She was 71.
Alley's children, True and Lillie Parker, announced the actress had died from cancer. In a statement to PEOPLE, True and Lillie confirmed that Alley died on Monday.
"We are sad to inform you that our incredible, fierce and loving mother has passed away after a battle with cancer, only recently discovered," they said in a statement.
"She was surrounded by her closest family and fought with great strength, leaving us with a certainty of her never-ending joy of living and whatever adventures lie ahead," they continued. "As iconic as she was on screen, she was an even more amazing mother and grandmother."
Aaron Rapoport/Corbis/Getty Kirstie Alley on Cheers
The siblings added how their mother's "zest and passion for life, her children, grandchildren and her many animals, not to mention her eternal joy of creating, were unparalleled and leave us inspired to live life to the fullest just as she did."
They also thanked the "incredible team of doctors and nurses" at the Moffitt Cancer Center.
Instagram Kirstie Alley
The statement concludes with True and Lillie thanking Alley's fans, sharing, "We thank you for your love and prayers and ask that you respect our privacy at this difficult time."
The statement was also shared on Alley's Instagram page.
Vinnie Zuffante/Michael Ochs Archives/Getty Kirstie Alley
Following the news, Alley's friend and former costar John Travolta paid tribute to the actress on social media.
"Kirstie was one of the most special relationships I've ever had. I love you Kirstie," he shared alongside a snap of the late star. "I know we will see each other again."
Valerie Bertinelli also shared her condolences on Twitter, writing, "Oh Kirstie, Rest in Peace"
Alley's last Instagram video was posted in September when she announced that was joining Cameo and fans could request "funny or sincere" messages from her using the platform. Her Cameo page has since been taken down.
Alley rose to fame in 1987 when she starred as Rebecca Howe on NBC's Cheers. She earned a Golden Globe for best actress and an Emmy for outstanding lead actress for her part in the Boston-based series in 1991.
She went on to receive her second Emmy win for her portrayal of Sally Goodson in David's Mother in 1994.
Alley also appeared on television shows including Veronica's Closet (1997-2000), Fat Actress (2005), Kirstie (2013-2014), and Scream Queens (2015-2016), as well as films like Star Trek II: The Wrath of Khan (1982), Summer School (1987), Look Who's Talking (1989), It Takes Two (1995) and Drop Dead Gorgeous (1999).
Never miss a story — sign up for PEOPLE's free daily newsletter to stay up-to-date on the best of what PEOPLE has to offer, from juicy celebrity news to compelling human interest stories
In 2010, her life was chronicled on the A&E reality TV series Kirstie Alley's Big Life. She also competed on season 12 of Dancing with the Stars in 2011, and season 7 of The Masked Singer in 2022.