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The actress, 58, joked about the musician, 45, in an Instagram video on Tuesday that showed her reading one of West's recent Instagram posts.
The line Cox singles out from the since-deleted post read, "I actually didn't write the [tweet] that said 'Friends wasn't funny either' but wish I had."
While listening to West's 2008 song "Heartless," Cox zooms in on the words "Friends. Wasn't. Funny." With that, she turns off the song.
"I bet the old Kanye thought Friends was funny," she captioned the video, adding a sad face emoji.
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Around the same time, fans had begun referencing the "Old Kanye" in order to differentiate between the rapper's early work and his evolving persona, including a Christian rap album.
Aniston warned her followers of West's presidential bid: "It's not funny to vote for Kanye. I don't know how else to say it. Please be responsible."
Someone then fabricated West's Twitter to make it seem like West was slamming Friends.
"I'd love to know who thought of that," West noted in his recent Instagram post. "I like to post comments."
Brad Barket/Getty for Fast Company Kanye West
West's comment came in the middle of an Instagram rant — mainly pertaining to his professional relationships with brands Gap and Adidas. Many of the posts have since been deleted from his Instagram feed.