In addition to the "Senorita" singers, who are nominated for multiple awards, Bad Bunny, J Balvin, Lil Nas X, Lizzo, Big Sean, A$AP Ferg, Fetty Wap, H.E.R, Jonas Brothers, Rosalia, Normani and Ozuna will be performing.
Another first will be when Miley Cyrus hits the stage to perform "Slide Away," which will be the first time she's hit the stage since announcing her split from Liam Hemsworth.
The network also revealed that Missy Elliott will be honored with this year's Michael Jackson Video Vanguard Award and, like her predecessors, will take the stage for a special performance. Past recipients include Jennifer Lopez, Pink, Rihanna, Kanye West and Beyonce.
The VMAs will close with a collaborative performance by Queen Latifah, Naughty by Nature, Redman, Fetty Wap and Wyclef Jean.
Fans can still vote for the "Best New Artist" award on vma.mtv.com. The 2019 MTV VMAs, hosted by comedian Sebastian Maniscalco, will air live from the Prudential Center in Newark, New Jersey, on Monday, Aug. 26 at 8 p.m. ET/PT.
In the meantime, check out ET's exclusive interview with this year's host: