Bob Saget Had an It's a Wonderful Life Moment When John Stamos Threw His 60th Birthday Party

John Stamos helped his longtime friend and Full House costar Bob Saget realize the impact he'd had on others as Saget entered what would be the final years of his life.

Just eight months before his sudden death at the age of 65, Saget recorded a candid interview for the Til This Day with Radio Rahim podcast. On Tuesday, PEOPLE exclusively shared the first part of the conversation in which Saget discussed how mortality "has fortunately changed me."

PEOPLE can also exclusively share the May 2021 chat's second installment, which Luminary released on Wednesday. In it, Saget shared how Stamos throwing him a 60th birthday party sparked an epiphany about how he had changed others' lives for the better.

"I've had many different cathartic moments," Saget explained to host Radio Rahim. "One of the hardest things I ever went through, even with all the deaths, was being divorced. So that was around 42. And The Motorcyclist's Guide to the Galaxy says the secret to life is 42. Something happens at 42."

"I do think that was around the time," he continued. "We all have many poignant moments and they do seem to have an age tag on them. Fifty is a big one. Sixty hit me very hard, but a friend of mine threw a big party for me that I didn't expect it to be — it was Stamos."

"I found out how much love that I had given to receive so much love from people," Saget added. "This isn't without other hardships that were happening at the same time, just personal things. But I really started to go, You mean something."

Stephen Lovekin/Getty Images John Stamos and Bob Saget

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This realization was so strong that Saget compared it to the 1946 film, It's a Wonderful Life, starring James Stewart and Donna Reed.

"It's like It's a Wonderful Life when [Stewart's character] George Bailey ... wants to kill himself. The movie starts, he's on a bridge. He's going to kill himself. And then an angel takes him through his life and shows him what would've happened had he not existed," he explained. "And I know for a fact that I have helped people."

He continued, "I know that I have given a lot of love to people because I have a lot. I have an extreme amount. I was raised with it. It's what helped me to survive and stay sane. It's helped me not let myself die."

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Getting even more candid, Saget revealed that there were moments of his life where "I'd be on a plane and didn't care if it went down."

"I looked around and went, they don't look happy either, so it'll be fine," he admitted. "That's all being a comic, thinking, 'Joke.' But then doing this stuff for people, with all the philanthropic stuff I can do, and people thank me for helping them further the research for scleroderma to try to save people's lives."

He added, "We can't say save people, but we can sure help to try to facilitate it. And mental health is a big thing I'm getting more involved in now to try to put my name on it and help people because I've had it in my life for so long."

Mike Coppola/Getty Bob Saget

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Saget died unexpectedly on Jan. 9, and an autopsy later revealed he had died from head trauma consistent with some kind of fall.

Prior to his death, Saget spent his life dedicated to charitable work, particularly after his sister Andrea died of a brain aneurysm in 1985, and his other sister, Gay, died from the autoimmune disease scleroderma in 1994.

Coincidentally, Saget had actually started work with the Scleroderma Research Foundation a few years prior to Gay's diagnosis, he told NIH Medline Plus Magazine in 2019.

"I got a call from someone I did not know asking me to host a comedy fundraiser for a disease I knew very little about," the actor recalled of speaking to founder Sharon Monsky. "I said yes and hosted the event, which starred Ellen DeGeneres, Rosie O'Donnell and others. Little did I know that just a few years later, my sister would be diagnosed with the disease."

Saget spun his grief into the 1996 TV movie For Hope, a story of a woman with scleroderma (played by Dana Delany) loosely based on Gay's story. The piece helped raise awareness around the disease, and Saget continued his advocacy by eventually taking a seat on the Scleroderma Research Foundation board and hosting the annual Cool Comedy, Hot Cuisine fundraiser, melding standup from the Full House star and his famous friends with meals cooked by top chefs. To date, the event has raised $25 million toward research and treatment.

In a May 2021 Instagram post, Saget called it "one of my life's missions to help find a cure for this disease." At the time of his death, the Scleroderma Research Foundation remembered him as a "relentless champion" for patients.

To donate to the Scleroderma Research Foundation in Saget's memory, click here.