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The Golden Globe winner, 69, cited "irreconcilable differences" as he filed to divorce Arielle Lorre (née Mandelson), according to court documents obtained by TMZ. The pair ended things in May after they tied the knot in Oct. 2018.
The couple confirmed the divorce in a statement to PEOPLE: "It is with mutual consideration and respect that we have decided to separate.
"Our plan is to move forward in different directions but with great love, admiration and gratitude for the time we shared," they added. "We ask that you respect our privacy during this difficult time. Thank you for your support."
Chuck will pay spousal support and attorney's fees in accordance with a prenuptial agreement they signed, TMZ reported. The couple does not have children together.
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The Dharma & Greg creator was married to his business partner Paula Smith from 1979 to 1992 and they share daughters Nicole and Asa. He was also married to Playboy Playmate Karen Witter from 2001 to 2010.
Also the creator of Cybill, Mom, The Kominsky Method and Bob Hearts Abishola, he is the 13th highest-paid entertainer of 2022 ($100 million), according to Forbes.
Arielle, a wellness influencer with more than 287,000 Instagram followers, shared some musings Sunday on TikTok. "I don't know who needs to hear this but... Don't lose hope. Please believe there are a thousand beautiful things waiting for you. Sunshine comes to everyone who feels rain," she wrote in a video.